This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Many clinical research genomics teams have built deep expertise around short-read analysis. They know how to assess data quality, align reads, call variants, weigh evidence, and connect genomic findings…
Last updated: 03 April 2026 Welcome to the Sequencing 101 blog series — where we will provide introductions to sequencing technology, genomics, and much more. If you’re not immersed…
Sequencing is the backbone of modern genomics. It has evolved over time, and as platforms grow to be faster and more accurate, researchers are finding new ways to maximize…
Today’s genome sequencing is nothing short of transformative. But the technology’s true potential isn’t unlocked by chemistry alone, it’s the software that brings it to life. If sequencing is…
Epigenetics is all about understanding how gene activity can change without altering the DNA sequence itself. Think of it as a “volume control” for your genes, turning them up…
The genetic blueprint of every living organism, from humans to microbes, is written in DNA. This blueprint is shaped by a remarkable phenomenon: genetic variation. These variations, or differences…
Last updated: 16 April, 2026 In the rapidly advancing field of genomics, choosing the right long-read sequencing technology is key to meeting your experimental goals smoothly and successfully. To…
Microorganisms form the foundations of life on Earth. They shaped our planet long before we were here, and continue to shape our environments and our lives. Understanding microbial…
Over the last 50 years, many monumental achievements in genetics and biology have unfolded before our eyes. From the invention of DNA sequencing technologies to the completion of the human…
In the field of genetics, the concept of tandem repeats has been both scientifically fascinating, experimentally challenging, and motivating for technology development. As DNA sequencing technologies and analysis tools have…
Last updated: 24 April 2026 If you have ever clicked around the PacBio website, or attended a workshop or webinar discussing PacBio long-read sequencing technology, then you have probably seen…
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…
Updated on March 2, 2023 Rare diseases are defined as diseases that affect a small number of people — fewer than 1 in 2,000 in the European Union and…
If you are like most of us at PacBio, you likely learned how to extract DNA in a high school or college biology class, or maybe even in your…
Updated on February 24, 2023. Originally published September, 2016. In recent interactions with the scientific community, we’ve seen a growing number of questions around scaffolding genome assemblies. We thought…
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