January 30, 2025 | Epigenetics
Sequencing 101: Epigenetics
Epigenetics is all about understanding how gene activity can change without altering the DNA sequence itself. Think of it as a “volume control” for your genes, turning them up…
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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
October 24, 2024 | Sequencing 101
What are genomic variants and why do they matter?
The genetic blueprint of every living organism, from humans to microbes, is written in DNA. This blueprint is shaped by a remarkable phenomenon: genetic variation. These variations, or differences…
July 18, 2024 | Sequencing 101
Sequencing 101: Comparing long-read sequencing technologies
In the rapidly advancing field of genomics, choosing the right long-read sequencing technology is key to meeting your experimental goals smoothly and successfully. To make an informed decision,…
June 13, 2024 | Metagenomics
Sequencing 101: Metagenome-assembled genomes
Microorganisms form the foundations of life on Earth. They shaped our planet long before we were here, and continue to shape our environments and our lives. Understanding microbial…
December 19, 2023 | Sequencing 101
Sequencing 101: Structural variation
Over the last 50 years, many monumental achievements in genetics and biology have unfolded before our eyes. From the invention of DNA sequencing technologies to the completion of the human…
November 22, 2023 | Human genetics research
Sequencing 101: Tandem repeats
In the field of genetics, the concept of tandem repeats has been both scientifically fascinating, experimentally challenging, and motivating for technology development. As DNA sequencing technologies and analysis tools have…
August 8, 2023 | Sequencing 101
Sequencing 101: SBB sequencing
Since the inception of next generation sequencing (NGS) more than a decade ago, short-read sequencing accuracy has seen only marginal improvement. Having achieved a level of precision thought to be…
July 6, 2023 | Sequencing 101
Sequencing 101: The SMRT Cell in PacBio long-read sequencing
If you have ever clicked around the PacBio website or attended a workshop or webinar discussing PacBio long-read sequencing technology, then you have probably seen or heard about SMRT (Single…
May 18, 2023 | Human genetics research
Sequencing 101: Sequencing coverage
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…
June 24, 2021 | Sequencing 101
Sequencing 101: How does whole genome sequencing help us understand rare diseases?
Updated on March 2, 2023 Rare diseases are defined as diseases that affect a small number of people — fewer than 1 in 2,000 in the European Union and…
May 10, 2021 | Sample + library preparation
Sequencing 101: DNA extraction — tips, kits, and protocols
If you are like most of us at PacBio, you likely learned how to extract DNA in a high school or college biology class, or maybe even in your…
February 3, 2021 | Sequencing 101
Genomes vs. genNNNes: the difference between contigs and scaffolds in genome assemblies
Updated on February 24, 2023. Originally published September, 2016. In recent interactions with the scientific community, we’ve seen a growing number of questions around scaffolding genome assemblies. We thought…
December 10, 2020 | Sequencing 101
Sequencing 101: ploidy, haplotypes, and phasing — how to get more from your sequencing data
Geneticists often point out that a human does not have “a” genome but rather two genomes: one inherited from the mother and another from the father. The number of…
July 23, 2020 | Sequencing 101
Sequencing 101: what’s the value of sequencing full-length RNA transcripts?
The study of genomics has revolutionized our understanding of science, but the field of transcriptomics grew with the need to explore the functional impacts of genetic variation. While different tissues…
July 7, 2020 | Sequencing 101
Sequencing 101: from DNA to discovery — the steps of SMRT sequencing
Starting a sequencing project can be daunting. First of all, there are several types of sequencing technologies, each based on unique processes. At PacBio, we use a technology called Single…
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