This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Many genes central to human disease research sit in regions of the genome that are complex and difficult to sequence. Repeat expansions, genes with highly similar pseudogenes, and loci…
For clinical research laboratories evaluating long-read sequencing, the central question is often not whether longer reads are useful. The value is clearest in the places where conventional approaches have…
In genomics, every lab is chasing the same trio of workflow priorities: working toward results that are accurate, flexible in application, and efficient in practice. For labs focused on…
Genome editing technologies are transforming the development of next-generation therapeutics. From CRISPR-Cas systems to base and prime editors, these approaches offer unprecedented opportunities to correct disease-causing mutations and engineer…
In genome editing, precision is the goal, but biology has a way of introducing variation of its own. Genetic mosaicism occurs when different genetic variants coexist within the same…
As many as 7 in 10 people carry at least one pathogenic genetic variant, even if they have no family history of disease1. That means most couples could unknowingly…
We just wrapped up the European Society of Human Genetics (ESHG) Conference in Milan Italy, surrounded by researchers, collaborators, and a shared focus on the future of human genomics….
Onso short-read sequencing systems are no longer available through PacBio Big things are happening at PacBio! The latest launches of the Vega system and SPRQ chemistry are creating quite…
In genomics, DNA is often compared to a cookbook, filled with recipes that guide the cells in your body. But where do tandem repeats fit into this analogy? Think…
The combined accuracy, read length, and coverage uniformity of PacBio HiFi sequence reads enables the characterization of many previously inaccessible regions in the genome. Two new preprints by Oscar Rodriguez,…
Long-read PacBio HiFi sequencing has made transformative contributions to many areas of genomics over the past few years, including de novo assembly, calling of all variant types, full-length phased targeted…
Cotton crops the world over have benefited from the pest-killing protein from Bacillus thuringiensis (Bt), first used in sprays and then, in 1996, transgenic crops, resulting in reduced insecticide use,…
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