Infectious disease research

Discover better vaccines, treatments and outcomes with full characterization of pathogens, their mobile elements and communities.

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Accelerate your research with in-depth genomic profiling

Comprehensive genetic information provided by Single Molecule, Real-Time (SMRT) sequencing has radically increased our understanding of microbial genomics, pathogenicity, and antimicrobial resistance. The PacBio systems empower scientists to:

Learn how other scientist have used SMRT sequencing to advance infectious disease research:

Spotlight

Decipher genome complexity in pathogens using SMRT sequencing

Scientists were able to successfully work through the well-known AT-bias challenge of the Plasmodium falciparum genome. De novo assembly revealed novel insights for genome architecture and complexity, providing a reference to better understand virulence, drug resistance and disease transmission. Explore this research further:

Vembar, S.S. et al., 2016. Complete telomere-to-telomere de novo assembly of the Plasmodium falciparum genome through long-read (>11 kb), single molecule, real-time sequencing. DNA Research, 23(4), pp.339–351.

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Spotlight

Single-molecule sequencing to track HIV-1 mutations

The development of novel circular consensus algorithms enabled the tracking of viral evolution of the K103N drug resistant associated mutation in clinical samples. Explore this research further:

Laird Smith, M. et al., 2016. An improved circular consensus algorithm with an application to detect HIV-1 Drug Resistance Associated Mutations (DRAMs). In 2016 ASM Microbe. New Orleans, LA.

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