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Infectious disease research

Discover better vaccines, treatments and outcomes with full characterization of pathogens, their mobile elements and communities.

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Accelerate your infectious disease research with in-depth genomic profiling

Comprehensive genetic information provided by Single Molecule, Real-Time (SMRT) sequencing has radically increased our understanding of microbial genomics, pathogenicity, and antimicrobial resistance. The PacBio systems empower scientists to:

Learn how other scientists have used SMRT sequencing to advance infectious disease research:

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Meeting the threat of antimicrobial resistance with HiFi sequencing and artificial intelligence

After conducting a battery of technology comparisons, OpGen’s Ares Genetics has adopted PacBio HiFi microbial whole genome sequencing. The company believes the read length and high accuracy of HiFi data will enable it to develop a suite of cutting-edge AI solutions with potential to revolutionize the way we combat the spread of antimicrobial resistance.

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PacBio-Powered Analysis Indicates Methylation Makes TB Pathogen So Wily

Scientists have long struggled to explain the success of Mycobacterium tuberculosis in the face of effective therapeutics. Tuberculosis (TB) kills more than 1 million people annually, and has a remarkable ability to develop resistance to drugs despite its stable genome. But now, a study from researchers at San Diego State University and other institutions strongly suggests that methylation rather than genome sequence gives M. tuberculosis its broad phenotypic range.

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Spotlight

VIRAL EVOLUTION: ASSAYING HOW THE PAST SHAPES THE FUTURE

SARS-CoV-2 mutations in the spike receptor binding domain (RBD) not only directly impact ACE2 receptor affinity but may also modulate the impact of future mutations. Here, a HiFi screening assay is used to measure how individual RBD mutations present in widely circulating variants affect the ACE2 binding affinity of all possible subsequent single amino-acid mutations.

Starr, et. al. (2022) Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution. Science.

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DECONVOLUTING COMPLEX VIRULENCE GENE SYSTEMS

The deletion of individual virulence genes from L. pneumophila genomes that contain a wealth of such genes does not yield growth phenotypes, making it difficult to connect effector genotype to phenotype. To deconvolute redundancy and synergy in this gene family, the authors developed a HiFi sequencing assay for titratable, multiplex gene knockdown.

Ellis, N.A. (2021) A multiplex CRISPR interference tool for virulence gene interrogation in Legionella pneumophila. Communications Biol.

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