Infectious disease research

Discover better vaccines, treatments and outcomes with full characterization of pathogens, their mobile elements and communities.

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Accelerate your research with in-depth genomic profiling

Comprehensive genetic information provided by Single Molecule, Real-Time (SMRT) sequencing has radically increased our understanding of microbial genomics, pathogenicity, and antimicrobial resistance. The PacBio systems empower scientists to:

Learn how other scientists have used SMRT sequencing to advance infectious disease research:

Spotlight

VIRAL EVOLUTION: ASSAYING HOW THE PAST SHAPES THE FUTURE

SARS-CoV-2 mutations in the spike receptor binding domain (RBD) not only directly impact ACE2 receptor affinity but may also modulate the impact of future mutations. Here, a HiFi screening assay is used to measure how individual RBD mutations present in widely circulating variants affect the ACE2 binding affinity of all possible subsequent single amino-acid mutations.

Starr, et. al. (2022) Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution. Science.

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Spotlight

DECONVOLUTING COMPLEX VIRULENCE GENE SYSTEMS

The deletion of individual virulence genes from L. pneumophila genomes that contain a wealth of such genes does not yield growth phenotypes, making it difficult to connect effector genotype to phenotype. To deconvolute redundancy and synergy in this gene family, the authors developed a HiFi sequencing assay for titratable, multiplex gene knockdown.

Ellis, N.A. (2021) A multiplex CRISPR interference tool for virulence gene interrogation in Legionella pneumophila. Communications Biol.

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