Cancer research solutions
In order to fulfill the promise of cancer precision medicine, a better understanding of cancer’s complex biology is needed. PacBio’s highly accurate long reads allow you to uncover novel isoforms, fusions, and structural variants with unmatched accuracy.
RNA ISOFORM + FUSION DISCOVERY
Cancer exhibits widespread RNA dysregulation. The Iso-Seq method uncovers the full repertoire of alternative splicing and fusion events.
STRUCTURAL VARIANT DETECTION
Structural variants (genomic differences ≥50 base pairs) are one of the main drivers of cancer. Most structural variants are too large to reliably discover with short-read DNA sequencing.
Alternative splicing (AS) results in the generation of multiple RNA isoforms from a single gene, greatly increasing both transcriptomic and proteomic diversity. AS controls which introns are removed from premRNAs and which exons are combined to form the final messenger RNA (mRNA).¹
Cancer research in action
Complex oncogene amplifications revealed
A detailed map of structural variations in breast cancer.
The RNA Isoform Landscape of Cancer
Learn how PacBio’s accurate long-read RNA sequencing provides true discovery power of cancer-related RNA isoforms and allows for the understanding of molecular mechanisms underlying cancer biology in this webinar.
Delivering new insights into cancer research
Meredith Ashby highlights the value of SMRT sequencing for deeper understanding of tumors at the genomic and transcriptomic level.