PacBio provides complete workflows and all the consumable components you need to perform Single Molecule, Real-Time (SMRT) sequencing.

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Long, accurate reads are only a few steps away

Template preparation

  • Convert your samples (genomic DNA, cDNA, or amplicons) into a SMRTbell library
  • Perform manually at the benchtop or by an automated liquid-handling system

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  • Multiplex samples to improve efficiency

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Annealing, Binding, and Cleanup (ABC)

  • Bind primer-annealed SMRTbell templates to a DNA polymerase in preparation for sequencing

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  • Utilize SMRT Cells and SMRT sequencing reagents required for on-instrument sequencing
  • Order multi-well plates, septa, and tips specifically designed and optimized for use with PacBio systems

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Featured SMRT consumables

New library prep consumables for Sequel II systems

We’re delighted to introduce our new SMRTbell prep kit 3.0 and our new Binding kits 3.1 and 3.2. These new consumables accelerate sample preparation times, lower DNA input requirements, and simplify protocol guidance across applications. We also now offer single collection versions of our SMRT Cell 8M and Sequencing kit and consumables, offering users the flexibility to run small, single SMRT Cell runs when convenient.

Learn how these consumables can elevate your whole genome sequencing, variant detection, epigenome analysis, and full-length RNA sequencing research with quick turnaround times to characterize SNPs, structural variants, splice isoforms, and improved genome annotation with high accuracy.

Learn more about the Sequel II and IIe systems.

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Featured SMRT consumables

New HiFiViral SARS-CoV-2 Kit for COVID-19 surveillance and multiplex up to 96 samples with the new SMRTbell barcoded adapter Plate 3.0

PacBio is excited to announce the availability of the new HiFiViral SARS-CoV-2 kit, an easy-to-use kitted solution for COVID-19 surveillance. This new solution offers robust performance on novel variants, enabling comprehensive detection of all types of mutations.

We are also thrilled to share the arrival of the SMRTbell barcoded adapter plate 3.0, which allows multiplexing of up to 96 samples on the Sequel II and IIe systems.

Are you designing experiments? Use this quick reference overview for current recommendations to help you get started.

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Sample prep

Nanobind HMW DNA extraction + Short-Read Eliminator Kits


Micro-, nano-, and single-molecule technologies to streamline every step in the genomics workflow


Get rid of short DNA quickly and efficiently

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Learn more about our applications

SMRT sequencing can sequence essentially any DNA strand: long, short, or AT/GC rich across PacBio applications.

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Whole genome sequencing

For humans, plants, animals, and microbes including de novo sequencing and variant detection

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Understand variants among bacterial, viral and cancer cell populations

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RNA sequencing

In-depth analysis of cDNA sequences across the entire transcriptome or targeted genes

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Detect DNA modifications in your samples while you sequence on the PacBio platform

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Targeted sequencing

Study relevant genome targets across any regions of interest

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Talk with an expert

If you have a question, need to check the status of an order, or are interested in purchasing an instrument, we're here to help.