PacBio sequencing delivers the data that empowers biodiversity and conservation initiatives with exceptional multiomic insights. Our state-of-the-art technologies enable you to comprehensively document and delve into the hidden wonders of the biosphere and launch campaigns to safeguard them for future generations.
Animal population health
Correctly identify at-risk populations and develop action plans to protect endangered species and habitats from things such as increased genetic drift, inbreeding depression, and reduced geneflow.
Climate change and the environment
Get the granular information you need to evaluate a species’ ability to adapt to ecological and environmental change using high-quality whole-genome sequences, transcriptomes, and epigenomes available.
Grasp how aquatic species adapt to extreme environments and explore how complex genotypes like bioluminescence evolve with full-length transcriptomes and reference-quality genome assemblies. Such information is vital in guiding efforts to protect life in our global ocean.
Protect biodiversity for people and the planet
Species loss and the degradation of global biodiversity threaten the air, water, and food supplies that we all depend on. PacBio supplies the world’s most sophisticated mulitomics technologies for exploring biological complexity and arming conservation initiatives with the best data possible for preserving our living world.
HiFi sequencing can be used to construct and phase the most detailed reference genomes possible, from blue whales to single cells. Moreover, accurate long reads are capable of characterizing entire biological communities with HiFi metagenomic and metabarcoding techniques. 5mC methylation detection allows you to glimpse gene activity of any organism with stunning clarity without any changes to library prep.
The Iso-Seq method brings the length and accuracy of HiFi sequencing to transcriptomics to enhance your understanding of gene expression and how organisms respond to their ecological contexts.
Combined, these technologies give biodiversity experts the ability to better understand the ecology and conservation needs of any species. Such detailed multiomic information may even hold promise for improving human health through bioprospecting and can serve as a hedge against extinction.
“We urge researchers to take advantage of new genomic technologies that provide an opportunity to explore, catalog, and mine the immense diversity of information contained within wild species before they are lost.”— Marks, et al., Nature Plants, 2022
Common questions about biodiversity
Biodiversity in action
Earth Day 2022
Learn how some of the world’s most ambitious biodiversity consortia are partnering with PacBio to generate hundreds of thousands of reference quality genomes spanning the entire tree of life.
Targeted sequencing best practices
Explore how to combine HiFi long reads with targeted sequence capture for a comprehensive view of specific genomic regions of interest, regardless of size.
Whole genome sequencing best practices
Look at recommended workflows for assembling reference-quality genomes of everything from insects and big cats to giant coastal redwoods, de novo.
Metabarcoding of fungi and other eukaryotes
Explore how HiFi sequencing is being used to help researchers peer deep into the evolutionary tree of life to better understand when and how eukaryotic lineages colonized different habitats.
Learn how some of the world’s most ambitious biodiversity consortia use HiFi sequencing to assemble reference genomes of the highest quality, for the benefit of science and the preservation of biological diversity globally.
Assemble and phase reference quality genomes for a target species like never before with the incredible accuracy and read length of HiFi sequencing. Genomic data of such exceptional quality makes it easier to ascertain true genetic diversity and correctly identify at-risk populations.
Inform your conservation action plans using detailed and actionable HiFi genomic information on areas of concern like genetic drift, inbreeding depression, and reduced geneflow.
See how researchers deployed HiFi sequencing to understand the population genetics of the kakapo and develop plans for its recovery.
Biodiversity for climate change
Glimpse how species adjust to climate change and evaluate the adaptive potential of populations to cope with environmental instability using the power of HiFi multiomic solutions.
- Construct phased, reference-quality genomes to capture the full genetic potential of individuals and compile pangemomes to understand the genotypic wealth hidden within entire populations or species.
- Use 5mC methylation detection to reveal potentially heritable changes in gene expression of your target species.
- Deploy the Iso-Seq method to construct isoform-level transcriptomes for evaluating metabolic and adaptive potential and revealing the molecular mechanisms behind complex physiologies.
Biodiversity for marine conservation
Use HiFi sequencing to explore the genomes and transcriptomes of a wide variety of marine species and ecosystems. Accurate genomic data is vital in understanding how marine species adapt and evolve, and informs efforts to protect life in our oceans.
- Assemble high-quality genomes to better understand complex genotypes such as bioluminescence.
- Understand how fish adapt to harsh environments with full-length transcriptome sequencing with the Iso-Seq method.
- Identify, sequence, and multiplex genomic regions of interest without compromising amplicon size.
PacBio has partnered with the Earth BioGenome Project (EBP) to deploy the power of HiFi sequencing to catapult humanity into a new era of biodiversity conservation and comprehension. With the goal of sequencing and assembling genomes for all known eukaryotic species on the planet within ten years, the pursuit is challenging but the benefits are immeasurable.
Applications to fuel biodiversity research and discovery
Whole genome sequencing
Quickly and affordably create contiguous, complete, and correct de novo assemblies of even the most complex genomes like the 27 Gb coastal redwood.
Structural variant calling
Acquire high-sensitivity variant calls with low false discovery rates to gain actionable insights across populations.
Leverage the isoform sequence (Iso-Seq) method to obtain full-length cDNA sequences — from 5’ to the poly-A tail — to confidently characterize the full transcriptome.
Uncover hidden microbiome functions and confidently capture microbial species richness and diversity with the highest quality metagenomic data available — only with HiFi metagenomic sequencing.