HiFi difference
From eye-opening tech comparisons to inspiring examples of PacBio HiFi technology in action — this blog series explores what sets HiFi sequencing apart.
Featured article
THE HIFI DIFFERENCE – A BETTER CELL ATLAS WITH FULL-LENGTH ISOFORM SEQUENCING
Understanding the myriad of different cell types, states, and their functions is essential to understanding biology. Cell atlas projects and consortia aim to map different cell types in tissues, organs,…
Your guide to getting started
Have a sequencing question, application, or project in mind? There’s HiFi for that. Download the newest HiFi Starter Kit to explore where long-read sequencing fits and how to take the next step.
Long-read sequencing is not the trade-off it used to be: These are the 5 questions that show why
By Samantha Kalla, Field Application Scientist, PacBio For years, five variables have defined the trade-offs in sequencing: read length, accuracy, methylation, cost, and sample input. Pick long reads, accept…
Cancer genomics myths revisited: How advances in HiFi sequencing keep strengthening the evidence
In cancer genomics, assumptions have a short shelf life. Not long ago we published a blog series debunking several common myths about long-read sequencing. At the time, many of…
Long-read sequencing myths: debunked.
Part 6 — cell & gene therapy
Cell and gene therapy research is crucial for biopharma development, with HiFi long-read sequencing significantly enhancing many sequencing applications throughout the process. Even though AAV sequencing is one of…
Long-read sequencing myths: debunked.
Part 5 — microbiology
The organisms you study might be tiny, but the importance of the work you do is anything but. PacBio HiFi sequencing brings the microscopic world into sharp focus, offering…
Long-read sequencing myths: debunked.
Part 4 — plant and animal
The world is moving at a fast pace, isn’t it? Climate shifts, growing populations, and changing ecosystems are stacking up some serious challenges for species all over the planet, including…
Long-read sequencing myths: debunked.
Part 3 — cancer genomics
The complexities of cancer biology are famously tricky to decipher. Peering into the murky cancer genome and making sense of tumor mechanisms has long been the goal of researchers…
Long-read sequencing myths: debunked.
Part 2 — human genomics
Hearing “the end of the beginning” or “the dawn of a new era” might sound like a grandiose way to describe a scientific milestone. Would it surprise you to…
Long-read sequencing myths: debunked.
Part 1- HiFi sequencing
In the fast-evolving landscape of genomics, the pace can be dizzying, and the fear of falling behind is real. Genomic research undergoes constant change, so if you want to…
A HiFi movement: Transcript isoform resolved RNA sequencing
The books of life are fascinating yet challenging reads, owing to the complexity of the underlying biological processes and their alterations that lead to disease. Thanks to highly accurate HiFi…