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Meet The New Sequel IIe System

enhanced.
exceptional.
evolved.

HiFi reads allow the accurate and simultaneous detection of single nucleotide and structural variants, paving the way for advancements in human genetics and greatly expanding the utility of SMRT Sequencing. Generating HiFi reads directly on the Sequel IIe System now has the potential to further accelerate cost-effective access to this information-rich sequencing data.

– Fritz Sedlazeck, Ph.D., Assistant Professor, Human Genome Sequencing Center at Baylor College of Medicine

My sequencing center has seen the level of interest in projects to be run on our Sequel II System increase by over 100% this year, as compared to the previous year. Many of these projects are coming from investigators and collaborators that are new to my center, they are interested in using HiFi sequencing in their research.

– Bruce Kingham, Director, Sequencing and Genotyping, University of Delaware

The Oxford Genomics Centre, the Core Facility of the Wellcome Centre for Human Genetics, is excited to invest in Pacific Biosciences' Sequel IIe, introducing their highly-accurate long-read sequencing to Oxford and beyond. This advance will drive new developments in analyses from whole viral and microbiome sequences, to complete assemblies of complex structural regions of the human genome and their epigenetic footprints.

– Prof John Todd, Centre Director & Dr David Buck, Head of High throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics

It's amazing to see lower-cost human genome sequences coming from the Sequel II System approaching the quality and completeness of the human reference genome, which took billions of dollars and many years to produce.

– Jeremy Schmutz, Faculty Investigator, HudsonAlpha Institute of Biotechnology

PacBio sets the standard for long-read sequencing and this upgrade of their instrument should have high impact on genomics sciences.

– H. Steven Wiley, Judge for The Scientist 2019 Top 10 Innovations Awards

PacBio Sequencing is Helping Track New Variants of COVID-19

We are committed to supporting the efforts of government, academic, and commercial labs in their efforts to increase SARS-CoV-2 surveillance by sequencing

Sequence With Confidence
Using PacBio Highly Accurate Long Reads

Explore the advantages of the Sequel II and IIe Systems and SMRT Sequencing technology

 

Discover the Benefits for Your Research Focus

Human Biomedical
Research

Resolve hidden heritability and improve your understanding of genetic disease

Plant & Animal
Sciences

Accelerate basic research, agricultural improvements, and industrial biotechnology

Microbiology &
Infectious Disease

Improve global health, protect agriculture and livestock, and fuel discovery research

Explore the Range of Applications

Apply the versatility of SMRT Sequencing to reveal new insights

See What's New

New Protocol

HiFiViral for SARS-CoV-2 Workflow: Multiplexing 1.2 kb Amplicons for Full-Viral Genome Sequencing

Publication

The Plant Cell: Long-read Sequence Assembly: A Technical Evaluation in Barley

Blog

SMRT Grant Winners – Collaboration Reaches New Heights in Global Science Challenge

Event

Senckenberg Biodiversity Genomics Symposium

In the News

Mendelspod: PacBio and Labcorp Team Up on a Global Pan-Pathogen Surveillance Network

Publication

Int. J. Mol. Sci: Robust Detection of Somatic Mosaicism and Repeat Interruptions by Long-Read...

Event

SMRT Leiden 2021 – Young Investigator Virtual Conference

In the News

GenomeWeb (Subscription required): Long-Read Sequencing Emerges as Useful Tool to Study RNA Isoforms

Podcast

Bloomberg Radio: Hunting for Covid-19 Variants

SMRT Resources

PacBio Blog

News & Events