HiFi reads allow the accurate and simultaneous detection of single nucleotide and structural variants, paving the way for advancements in human genetics and greatly expanding the utility of SMRT Sequencing. Generating HiFi reads directly on the Sequel IIe System now has the potential to further accelerate cost-effective access to this information-rich sequencing data.
My sequencing center has seen the level of interest in projects to be run on our Sequel II System increase by over 100% this year, as compared to the previous year. Many of these projects are coming from investigators and collaborators that are new to my center, they are interested in using HiFi sequencing in their research.
The Oxford Genomics Centre, the Core Facility of the Wellcome Centre for Human Genetics, is excited to invest in Pacific Biosciences' Sequel IIe, introducing their highly-accurate long-read sequencing to Oxford and beyond. This advance will drive new developments in analyses from whole viral and microbiome sequences, to complete assemblies of complex structural regions of the human genome and their epigenetic footprints.
It's amazing to see lower-cost human genome sequences coming from the Sequel II System approaching the quality and completeness of the human reference genome, which took billions of dollars and many years to produce.
PacBio sets the standard for long-read sequencing and this upgrade of their instrument should have high impact on genomics sciences.
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HiFiViral for SARS-CoV-2 Workflow: Multiplexing 1.2 kb Amplicons for Full-Viral Genome Sequencing
Int. J. Mol. Sci: Robust Detection of Somatic Mosaicism and Repeat Interruptions by Long-Read...
In the News
GenomeWeb (Subscription required): Long-Read Sequencing Emerges as Useful Tool to Study RNA Isoforms