Microbial sequencing methods

Advancing our understanding of the microbial world through discovery-based research entails comprehensive analysis of microbial genomes, their interactions, communities, and environments in which they live.

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Single Molecule, Real-Time (SMRT) sequencing on the PacBio systems provides a deeper understanding of microbes and microbial communities by giving scientists the ability to:



The genome of a novel Streptomyces anulatus strain isolated from a Chinese medicinal herb was sequenced with PacBio and fully assembled to reveal 52 putative biosynthetic gene clusters, including numerous with significant differences from known clusters. Growth under diverse conditions produced two novel compounds, with more potential yet to be unlocked.

Liu, et. al. (2022). Exploration of diverse secondary metabolites from Streptomyces sp. YINM00001, using genome mining and one strain many compounds approach. Front Microbiol.

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Despite its importance as a clinical target, only 4 herpes simplex virus type 2 strains have complete genomes due to dense repeats and ~70% GC content. Here, scientists report the complete de novo assembly and annotation of an additional strain commonly used in research, HSV-2 strain G.

Chang, W. et. al. (2022). Complete genome sequence of herpes simplex virus 2 strain G. Viruses 14(3), 536; https://doi.org/10.3390/v14030536.

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A new standard in pathogen genomics

Detect, track, and characterize pathogens to a new standard of completeness and precision. PacBio® solutions offer exceptional accuracy and long read lengths to support a wide range of pathogen surveillance applications.

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