Public health + surveillance

Protecting global health is best accomplished through comprehensive surveillance, complete genomic information, and accurate tracking. Tremendous progress has been made since technology first enabled the routine sequencing of pathogenic microbes.

Connect with a PacBio scientist

Tertiary hero overlay
Sprite decoration

The complete picture

Build a more comprehensive genomic view of microbial pathogens

The advent of Single Molecule, Real-Time (SMRT) sequencing has radically increased the understanding of microbial genomics, pathogenicity, and antimicrobial resistance. The PacBio systems deliver the most comprehensive genetic information available, and with SMRT sequencing, federal agencies, healthcare centers, and other public health organizations have the ability to:

  • Generate complete genome assemblies and gain a deeper understanding of community-acquired and hospital associated infections and transmission.
  • Use microbial epigenetics to further characterize global outbreaks, pandemics, and epidemics.
  • Inform local and global preparedness and response to seasonal and annual infections by rapidly resolving viral populations.
  • Characterize microbial communities with culture-free methods to support surveillance and tracking foodborne pathogens

Solutions Guide

A new standard in pathogen genomics

Detect, track, and characterize pathogens to a new standard of completeness and precision. PacBio® solutions offer unmatched accuracy and long read lengths to support a wide range of pathogen surveillance applications.

Learn more

Spotlight

NEW INSIGHTS INTO NDM RESISTANCE IN HEALTH CARE SETTINGS

Large-scale sequencing and closed PacBio genomes link the spread and persistence of blaKPC carbapenem resistance in UK hospitals to the fluid exchange of mobile elements among plasmids capable of transfecting a broad range of hosts. The finding that horizontal transfer, rather than clonal expansion, is that main driver of increasing resistance has important implications for surveillance.

Stoesser, N., et. al. (2020) Genomic epidemiology of complex, multispecies, plasmid-borne blaKPC carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014. Antimicrob Agents Chemother, (64)5, p.e02244-19.

Sprite decoration

Spotlight

LONG READS SHED LIGHT ON THE SPREAD OF ANTIBIOTIC RESISTANCE IN FOOD SYSTEMS

Long read sequencing of 134 multidrug-resistant Salmonella strains revealed important trends and details about the spread of AMR resistance in our food systems, including chromosomal integration of plasmids and the potential for co-selection of AMR genes in the presence of heavy metals used in food animal production.

Li,C. et. al. (2021) Long-read sequencing reveals evolution and acquisition of antimicrobial resistance and virulence genes in Salmonella enterica. Front Microbiol, 12, doi: 10.3389/fmicb.2021.777817

Talk with an expert

If you have a question, need to check the status of an order, or are interested in purchasing an instrument, we're here to help.