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Sequence with confidence

The award-winning PacBio Sequel Systems are powered by Single Molecule, Real-Time (SMRT) Sequencing technology and deliver highly accurate long reads.

Setting a New Standard in Long-Read Sequencing

The Sequel II System has been recognized for its ability to generate longer reads with greater accuracy and throughput, at a significantly lower cost.

Get to know the Sequel II and IIe Systems and their cost-effective sequencing applications with our Interactive Brochure.

Explore our Latest System Release 

 

 

 

An Introduction to the Sequel II Systems

The PacBio Sequel II and IIe Systems provide all scientists with access to high throughput, cost effective, highly accurate long-read sequencing. Watch this short video to learn how the Sequel II and IIe Systems can help you be confident in your discoveries made possible with comprehensive views of genomes, transcriptomes, and epigenomes.

The Sequel System Family of Instruments

Sequel II and IIe Systems

Sequel System

Supported SMRT Cell SMRT Cell 8M SMRT Cell 1M
Number of HiFi Reads >99%* Accuracy Up to 4,000,000 Up to 500,000
Sequencing Run Time per SMRT Cell Up to 30 hrs Up to 20 hrs
Recommended Chemistry 2.0 3.0
Instrument Control Software v9.0  v8.0
SMRT Link
v9.0 v9.0
Performance Data Sequel IIe System Release Sequel System Release

 

Features of all PacBio Sequel Systems

*Number of HiFi reads is dependent upon the insert size and sample quality

 

SMRT Sequencing Applications

All Sequel Systems support the full range of SMRT Sequencing applications for generating genomes, transcriptomes, and epigenomes.

Whole Genome Sequencing

For humans, plants, animals and microbes including de novo sequencing and variant detection

Complex Populations

Understand variants among bacterial, viral and cancer cell populations

 

RNA Sequencing

In-depth analysis of cDNA sequences across the entire transcriptome or targeted genes

Epigenetics

Detect DNA modifications in your samples while you sequence on the PacBio platform

Targeted Sequencing

Study relevant genome targets across any regions of interest


Ready to Get Started?

 

Connect with a PacBio scientist to have your questions answered about the Sequel Systems or SMRT Sequencing Applications