Sequence with confidence
The award-winning PacBio Sequel Systems are powered by Single Molecule, Real-Time (SMRT) Sequencing technology and deliver highly accurate long reads.
Setting a New Standard in Long-Read Sequencing
The Sequel II System has been recognized for its ability to generate longer reads with greater accuracy and throughput, at a significantly lower cost.
Get to know the Sequel II and IIe Systems and their cost-effective sequencing applications with our Interactive Brochure.
Explore our Latest System Release
An Introduction to the Sequel II Systems
The PacBio Sequel II and IIe Systems provide all scientists with access to high throughput, cost effective, highly accurate long-read sequencing. Watch this short video to learn how the Sequel II and IIe Systems can help you be confident in your discoveries made possible with comprehensive views of genomes, transcriptomes, and epigenomes.
The Sequel System Family of Instruments
Sequel IIe System |
Sequel II System |
Sequel System |
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Supported SMRT Cell | SMRT Cell 8M | SMRT Cell 8M | SMRT Cell 1M |
Number of HiFi Reads >99%* Accuracy | Up to 4,000,000 | Up to 4,000,000 | Up to 500,000 |
Sequencing Run Time per SMRT Cell | Up to 30 hrs | Up to 30 hrs | Up to 20 hrs |
Recommended Chemistry | 2.0 | 2.0 | 3.0 |
Instrument Control Software | v10.0 | v9.0 | v8.0 |
SMRT Link |
v10.0 | v9.0 | v9.0 |
Performance Data | Sequel IIe System Release | Sequel II System Release | Sequel System Release |
Features of all PacBio Sequel Systems
- Automated consumable handling with integrated software
- Intuitive run setup and monitoring
- Flexible run time
- Walk away time up to 4 days
*Number of HiFi reads is dependent upon the insert size and sample quality
All Sequel Systems support the full range of SMRT Sequencing applications for generating genomes, transcriptomes, and epigenomes.
Whole Genome Sequencing
For humans, plants, animals and microbes including de novo sequencing and variant detection |
Complex Populations
Understand variants among bacterial, viral and cancer cell populations
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RNA Sequencing
In-depth analysis of cDNA sequences across the entire transcriptome or targeted genes |
Epigenetics
Detect DNA modifications in your samples while you sequence on the PacBio platform |
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Targeted Sequencing
Study relevant genome targets across any regions of interest |
Connect with a PacBio scientist to have your questions answered about the Sequel Systems or SMRT Sequencing Applications