ENVIRONMENTAL HEALTH SOLUTIONS
HiFi sequencing delivers data of exceptional breadth and accuracy to address complex challenges in environmental health. From characterizing diverse microbial communities across soil, water, and host-associated environments to uncovering the functional potential and interactions that shape ecosystem health, HiFi enables a more complete understanding of the natural world.
Microbial WGS
Sequence entire microbial genomes and plasmids to understand host-microbe dynamics.
Full-length 16S, ITS, and other rRNA sequencing
Profile bacteria or microeukaryotes in complex communities with species-level resolution.
Viral sequencing
Detect and fully phase viral populations to understand global threats to plant and animal health.
Understand and protect ecosystems and environmental health
Climate change, pollution, and habitat disruption are reshaping ecosystems across the planet. To address these challenges, it is essential to characterize the diversity, function, and interactions of organisms across environmental systems, from microbes to complex communities. Our sequencing tools support multiomic approaches across microbiology, ecology, metagenomics, and environmental health research.
- Reveal virulence and resistance potentials for pathogens with more complete whole genome information.
- Achieve species- and strain level resolution to profile bacteria, fungi, and other eukaryotes
- Generate among the highest quality and most complete MAGs per Gb compared to other sequencing technologies
COMMON ENVIRONMENTAL HEALTH QUESTIONS THAT HIFI SEQUENCING CAN HELP ANSWER
HiFi long reads improve taxonomic resolution in complex samples, enabling more accurate detection of rare and low-abundance species.
The combination of long read length and high accuracy allows HiFi sequencing to resolve small genetic differences, supporting confident species- and strain-level identification.
HiFi reads support precise taxonomic profiling while also capturing full length genes, providing insight into both community composition and functional potential.
HiFi metagenomics enables recovery of high quality, near complete genomes directly from complex samples without the need for reference databases.
EXPLORE PLANT + ANIMAL MICROBIOLOGY AT HIGH RESOLUTION
Bacteria, viruses, and fungi have critical influences on the health of plants, animals, and ecosystems. See how research groups are using HiFi sequencing to profile microbiomes in high resolution.
Introducing the Vega system – HiFi sequencing within reach
Bring the power of HiFi to every corner of the globe with the first benchtop PacBio long-read sequencing platform.
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Microbial WGS
Embark on a deeper exploration of microbial diversity with long, high-quality genomic reads to better understand bacteria, fungi, and other microorganisms. From complete genome assemblies that reveal antimicrobial resistance and metabolic potential, to comparative analyses that uncover evolutionary relationships across strains, HiFi sequencing helps resolve microbial biology with exceptional accuracy.
- Build reference-quality, complete microbial genomes to better understand species, strains, and their functions.
- Reveal SNPs, indels, and structural variants that drive adaptation, resistance, and phenotypic diversity.
- Capture genomic variation across isolates and populations to study microbial evolution and environmental dynamics.
Full-length 16S, ITS, and other rRNA sequencing
Capture a more complete picture of microbial communities with long reads that span full-length marker genes. Across soil, water, and host-associated samples, HiFi sequencing enables species- and strain-level resolution beyond what short read approaches can provide.
- Profile bacterial and fungal communities with full-length 16S, ITS, and other rRNA sequencing.
- Identify closely related species and strains with high-accuracy long reads.
- Characterize community composition across diverse environmental and host-associated samples.
Metagenome sequencing
Analyze complex environmental samples with long, high-quality reads that enable genome resolved metagenomics. HiFi sequencing supports recovery of complete genomes and functional insights directly from mixed microbial communities without reliance on references.
• Recover high quality, near complete genomes directly from complex environmental samples.
• Resolve repeats and separate closely related organisms within mixed communities.
• Characterize functional potential and diversity across microbiomes at scale.
Viral sequencing
Understand viral diversity with long, high-quality reads that provide a more complete view of viral genomes and their interactions with hosts. From environmental viromes to host-associated viruses, HiFi sequencing enables detailed characterization of viral evolution and function.
• Generate complete viral genomes to study diversity, evolution, and transmission.
• Detect variation across viral populations, including SNPs and structural changes.
• Investigate virus-host interactions across environmental and public health contexts.
Computational tools
COMPUTATIONAL TOOLS ACCELERATE METAGENOMIC DISCOVERY
PacBio provides open-source metagenomics tools and workflows designed specifically for HiFi sequencing data, including pipelines for taxonomic profiling, functional analysis, and recovery of high-quality metagenome assembled genomes (MAGs). The pb-metagenomics-tools resource includes reproducible workflows, tutorials, benchmarking datasets, and visualization utilities to help researchers get started with genome resolved metagenomics using HiFi reads.
Pricing tables
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