Menu

Biopharma

To develop potential treatments and cures for diseases, researchers need to draw on a variety of highly accurate sequencing data such as genomic, transcriptomic, DNA methylation and targeted sequencing data.

Connect with a PacBio scientist

Sprite decoration

Accelerate your research and development with highly accurate and comprehensive sequencing data

Whether you are conducting research on novel potential drug targets, biomarkers, or therapeutics such as gene therapies, PacBio offers a sequencing solution that can improve your chances of success and may reduce your time to market. Sequencing has become an integral part of the research and development process and helps to develop the critical understanding of determinants of health and disease on the molecular level.

HiFi sequencing allows you to overcome many limitations that short-read or less accurate long-read methods may pose and can play important roles in enhancing your research on

 

  • Target or biomarker identification
  • AAV gene therapies
  • CRISPR-Cas9 gene editing
  • Biologics development

Connect with a PacBio scientist

white icon for aav gene therapy

Gene therapy

Discover, verify, and improve AAV vector design with full-length, highly accurate AAV.

Learn more

Null

Gene editing

Assess on- and off-target CRISPR-Cas9 gene editing outcomes and conduct insertion site analysis.

Learn more

Null

Biologics R&D

Enhance your work on biologics, from plasmid sequencing, cell line verification, mRNA full length sequencing, to directed evolution.

Learn more

Sprite decoration

Brochure

HiFi solutions for cell and gene therapy research

Explore how HiFi sequencing can be used to support your gene and cell therapy research

Learn more

Sprite decoration

Identify novel drug targets and biomarkers quickly and confidently

PacBio is an established company providing quality data and excellent customer service to facilitate your research process. HiFi sequencing enables you to see what you cannot see with other methods to allow you to discover novel biomarkers or potential drug targets first.

Null

WGS

HiFi sequencing allows you to identify more variants than other methods and assess challenging regions while providing phasing information.

Learn more

rna sequencing white icon

RNA sequencing

There is increasing evidence that isoforms are critical to understanding health and disease.

Learn more

Null

DNA methylation

5mC information is critical to understanding gene regulation and is provided with every DNA sequencing run.

Learn more

Blog

Isoform level information leads to the development of novel ASOs for Parkinson’s disease

HiFi long-read sequencing economically provides highly accurate multi-omic data for all areas of the genome. Increase what you can see to include all variant types and transcripts at isoform level. A recent study used PacBio to identify a promising region in SNCA transcripts relevant to Parkinson’s disease, and used this information to design and test a novel antisense oligo (ASO).

Learn more

Sprite decoration

Video

A biopharma company uses HiFi sequencing to help in the development of novel AAV gene therapies

The speakers from Homology medicines use AAV genome sequencing as well as RNA sequencing to enhance their research and development beyond what short reads do.

Sprite decoration

HiFi sequencing to stratify ALS patients for personalized treatments

A novel study will use long-read sequencing to stratify patients suffering from amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The sequencing data will provide novel information on disease associated variants that short-read sequencing may not detect, as well as methylation information, to help match patients with supplements or treatments. Further research may uncover relevant biomarkers or novel targets.

Learn more

Video

Using long-read sequencing for directed evolution of novel AAV capsids

Directed evolution approaches can be limited by the sequence length that short-read sequencing allows. Irvin Garza of UT Southwestern overcame this obstacle by using long-read sequencing, which allowed him to introduce mutations in the cap gene of the AAV capsid in a much longer region. This lead to the discovery of several interesting candidates for novel capsids with desired tissue specificity to the central nervous system.

Sprite decoration

Featured long-read sequencing systems

PacBio long-read sequencers unlock the tools needed for novel gene therapy approaches.

Explore products

Talk with an expert

If you have a question, need to check the status of an order, or are interested in purchasing an instrument, we're here to help.