PacBio is partnering with 10x Genomics through the 10x Compatible Partner Program and PacBio Compatible to unlock a multidimensional approach to sequencing at exceptional resolution and accuracy. This partnership demonstrates compatibility of the new PacBio MAS-Seq kit for 10x Chromium single cell libraries to be paired with PacBio’s long read sequencing platforms.
Build your workflow with PacBio Compatible
We work with a wide range of industry-leading organizations to ensure the compatibility of products optimized for use in PacBio workflows. Our partners have been qualified by PacBio scientists to provide seamless integration and support for customers who are just starting out with PacBio sequencing or expanding their current capabilities.
Use the filters on the right to select by application, product line, or workflow step. Check all that apply.
Agilent is a compatible partner for end-to-end targeted sequencing workflows including automation, library prep, and data analysis. This partnership leverages the ClearSeq Comprehensive Cancer panel and the accuracy of SBB technology to confidently identify disease-associated variants and optimize the molecular profiling of cancers. Targeted sequencing is enabled by Agilent’s SureSelect Custom DNA Target Enrichment Probes and PacBio’s sequencing by binding (SBB) technology. Additionally, Agilent’s Femto Pulse instrument is recommended for accurate generation of large-insert libraries for de novo large genome sequencing projects and other PacBio applications leveraging multi-kilobase read lengths.
Learn more: Product note
BugSeq is a fully automated bioinformatics platform for microbiology labs. BugSeq powers the analysis of genomic and metagenomic data at global institutions with leading accuracy, cloud acceleration and intuitive analysis. The BugSeq platform is optimized for addressing the challenges of security, scalability, and collaboration in organizations that are pursuing genomic-based approaches to identify and characterize microbes. The BugSeq team is made up of experts in microbiology, computational biology and cloud computing who work tightly with partners to tackle some of the most exciting opportunities in microbiology, making it easier — and in many cases possible — to translate sequencing data into actionable results.
Shearing with the Megaruptor system leads to optimal long-read sequencing using PacBio systems prior to library preparation with the SMRTbell prep kits. The Megaruptor 3 system, recommended by PacBio for HiFi, microbial multiplexing and structural variants provides optimal DNA fragmentation from 5kb-100kb. The Megaruptor 3 comes with a default cassette that processes up to 8 samples at once, and Diagenode now offers a 12-sample cassette for 50% higher throughput that easily fits into your existing Megaruptor 3. The user-friendly system allows samples to be processed simultaneously without additional user input.
DNAnexus is a software partner with a platform to analyze large amounts of raw genetic data, share, collaborate, and integrate genetic data with other types of data, such as data from electronic medical records or imaging data.
Form Bio is a cutting-edge computational life sciences platform for research teams and enterprises. With an accessible, comprehensive, and collaborative platform alongside powerful AI-based solutions and bioinformatics services, Form Bio empowers scientists to efficiently and effectively harness the proliferation of data and computing power that has transformed the science of discovery. Form Bio offers end-to-end integration of the discovery process with intuitive and easy-to-use software applications, combined with an open and adaptable collaborative environment.
Google Health is a strategic development partner for DeepConsensus integration into the PacBio Revio system. Google Health’s DeepVariant software analysis of PacBio HiFi data won best performance in variant calling for all benchmark regions in the Precision FDA Truth Challenge v2.
Learn more: DeepVariant analysis using Revio data
Hamilton workstations are compatible automation solutions for PacBio sequencing platforms. Hamilton and PacBio have partnered to develop walk-away automation solutions for both High Molecular Weight (HMW) DNA extraction on the Nimbus Presto and the SMRTbell Prep Kit 3.0 PacBio Library Preparation kits on the NGS Star to enable genomic workflows globally.
The MIRO CANVAS system is a compatible automation solution which uses digital microfluidics to provide walkaway library preparation for PacBio sequencing platforms. It fully automates PCR-free WGS library preparation of long DNA Fragments using PacBio’s SMRTbell Prep Kit 3.0 with 1-5 μg high quality, high molecular weight input DNA. The MIRO CANVAS system generates high quality results with total library quantity, HiFi yield, read length, read quality and structural variant detection comparable to manually prepared libraries.
Learn more: Application note
The Single Cell RNA Boost Kit from Jumpcode is designed to deliver approximately a 50% boost in gene and UMI sensitivity for single cell and spatial libraries with significant increase in isoform detection. This kit depletes abundant and uninformative fragments prior to sequencing such as ribosomal and mitochondrial transcripts and is compatible with the PacBio MAS-Seq kit.
The MP Biomedicals FastPrep 96 instrument offers a sophisticated high-throughput sample preparation solution tailored for PacBio long-read sequencing platforms. This instrument can shear up to 192 DNA samples at once, producing uniform, high-quality fragments, customizable to the desired size in as little as 8 minutes without requiring any supplementary reagents. Streamlining and simplifying the sample preparation process, the FastPrep 96 is compatible with the PacBio WGS workflow to deliver exceptional results.
Learn more: Technical note
NVIDIA’S invention of the GPU in 1999 sparked the growth of the PC gaming market, redefined modern computer graphics, and revolutionized parallel computing. More recently, GPU deep learning ignited modern AI — the next era of computing — with the GPU acting as the brain of computers, robots, and self-driving cars that can perceive and understand the world. NVIDIA is a data computation and storage partner of PacBio that has shown successful deep learning models to polish HiFi reads. PacBio sequencing data outputs can be analyzed by NVIDIA Parabricks®, the only GPU-accelerated computational genomics toolkit for secondary analysis, which delivers fast and accurate analysis for sequencing centers, clinical teams, and researchers.
Learn more: Parabricks Variant Detection Webinar
Qiagen is a partner for PacBio SBB workflows, providing end-to-end targeted sequencing including automation, library prep, and data analysis. Qiagen and PacBio are partnering on cfDNA workflows for the Onso sequencing platform.
Revvity offers vendor qualified, NGS library prep automated solutions for the PacBio HiFi Express Template Kit 2.0 and the SMRTbell Prep Kit 3.0. Available from bench-top to fully automated sized-systems and designed for 8 to 384 sample throughput workflows, no programming or method development is needed by the user. Revvity has hundreds of NGS workstations in the field and has a global team of NGS application, service, and sales experts. With an ever-growing library of vendor qualified NGS library prep methods, Revvity is an ideal partner for NGS automation solutions.
Sage Science’s electrophoretic DNA size selection instruments provide user-adjustable DNA size distributions with outstanding rejection of small fragments. Optimally sized SMRTbell® libraries improve HiFi sequencing results, providing better uniformity and higher quality. PacBio recommends three systems for size selection. The BluePippin processes 4 samples with sample inputs up to 5 ug. For higher throughput needs, the PippinHT can process up to 22 samples in a single run. The SageELF (1 or 2 samples per run) fractionates an entire sample into 12 contiguous size bins, provides the most flexibility in sizing, and produces the narrowest size distributions.
Sentieon is a data analysis partner for processing and accelerating PacBio FASTQ to VCF data processing. Sentieon’s DNAscope tool takes advantage of the improved quality and long read length of PacBio HiFi reads to perform quick and accurate variant calling using specially calibrated machine learning models.
Learn more: WGS Pipeline
Tecan offers multiplexed library preparation that is a compatible automation solution for PacBio sequencing platforms. The Tecan DreamPrep NGS Compact is a walkaway automation solution for NGS library prep with flexible configurations to deliver consistent, sequencing-ready libraries for a wide range of NGS protocols with minimal manual intervention that match different throughput requirements for your PacBio sequencer.
Learn more: Application note
Thermo Scientific™ KingFisher™ purification instruments automate the extraction of DNA, RNA, proteins, and cells. KingFisher instruments provide easy-to-follow protocols that remove manual steps and reduce overall processing time and errors associated with sample preparation while increasing the yield reproducibility of your results compared to the manual workflows. KingFisher instruments are compatible with PacBio® Nanobind® HT kits.
Learn more: Nanobind Extraction Automation
PacBio has partnered with Twist Bioscience to deliver long-read target enrichment panels. The initial portfolio of products focuses on challenging, medically relevant genes (Dark Genes panel) and pharmacogenomics (Long Read PGx panel). Custom panel capability broadens access to the benefits of long-read HiFi sequencing like accurate variant detection including structural variants and phasing. This partnership also combines the outstanding accuracy of SBB technology with the Twist Exome 2.0 panel: 50x coverage of >80% target bases. By partnering with Twist, PacBio can deliver a targeted sequencing solution that is high throughput and cost-effective while also being supported end-to-end.
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