Nanobind + SRE sample prep kits

Innovative solutions for high-molecular-weight (HMW) DNA sample prep

Order kits online

Tertiary hero overlay

Nanobind DNA extraction

Higher DNA quality means better HiFi data

Learn more Order kits online

Nanobind extracted DNA is optimized for HiFi sequencing. Our kits provide you with an all-in-one extraction experience that can be used with a wide range of sample types. The PanDNA kit supports manual high-quality extraction from cultured cells, bacteria, whole blood, tissue, plant nuclei, and insect samples in 1 to 2.5 hours. The Nanobind HT CBB kit enables automation of DNA extraction for human and animal blood, mammalian cells, and bacteria. Our HT kit is compatible with up to four robotic platforms and 96 samples that can be extracted in 2.5 hours.

Pan DNA icons for sample types

Sprite decoration

How does it work?

Nanobind kits contain specific reagents to process and lysate diverse sample types. Following lysis, the DNA binds to Nanobind disks which shield bound DNA from damage during extraction, resulting in HMW DNA. A final Short Read Eliminator (SRE) size selection step helps remove DNA fragments below 10 kb.

larger image of Automated workflow for sample prep image showing lysis, binding, washing, elution, library prep, sequencing and analysis


Automate DNA extraction and optimize your sample prep workflow for HiFi sequencing

PacBio Nanobind HT kits enable automation of DNA extraction, the first step of an end-to-end workflow that harnesses the power of HiFi sequencing. Nanobind HT kits are designed for whole human blood and mammalian cell samples and are compatible with four robotic platforms.

Learn more


Simple size selection for optimal HiFi result

Learn more Order kits online

SRE treatment following DNA extraction helps removing DNA molecules below 10 kB. It results in improved HiFi read length distribution and HiFi sequencing yield. The SRE workflow is fast, easy, and inexpensive using simple size selective precipitation. HMW DNA is precipitated by centrifugation and low molecular weight (LMW) DNA is washed away. Many samples can be process in parallel in 2 hours (10 min hands-on time). HT solution will be available soon.

Procedure + checklist

Removing short DNA fragments with the Short Read Eliminator (SRE) kit

This procedure describes the workflow for DNA size selection to remove molecules <10 kb using the SRE kit on HMW DNA before shearing and library preparation. The SRE kit is used for rapid size selection of unsheared HMW DNA samples. This method can significantly enhance mean read length by progressively depleting short DNA up to 10 kb.

Learn more

Sprite decoration

PacBio compatible products


PacBio Compatible   Qualified automation protocols   Kingfisher extraction scripts


Circulomics handbooks image

Procedure + Checklists

Quick and easy reference guides to learn all about Nanobind kits and how they enable HMW DNA extraction.

Learn more

stock image of paper fanning, curved to right

Guides + Overviews

Nanobind guides provide recommendations for hard-to-sequence sample types.

Learn more


Product inserts + SDS

Download product inserts and SDS.

Learn more

Sprite decoration


Did you know we have other resources for reports, papers, and videos?

Explore resources


Extract the highest quality HMW DNA using Nanobind DNA extraction kits.

Enhance read lengths by depleting short DNA using SRE size selection kits.

Our experts offer end-to-end support from extraction through library prep and sequencing.

Connect with a PacBio scientist

Image of Sequel IIe and Revio long-read sequencing systems - PacBio

Talk with an expert

If you have a question, need to check the status of an order, or are interested in purchasing an instrument, we're here to help.