Circulomics Nanobind + SRE Sample Prep kits
Innovative solutions for high-molecular-weight (HMW) DNA sample prep
END-TO-END WORKFLOWS FOR LONG-READ SEQUENCING AT SCALE
Extract the highest quality high molecular weight (HMW) DNA using Nanobind DNA extraction kits.
Enhance read lengths by depleting short DNA using SRE size selection kits.
Our experts offer end-to-end support from extraction through library prep and sequencing.
“Our kits enable customers to
focus on science
rather than stress over sample prep.”
— Dr. Kelvin Liu, Founder and CEO of Circulomics
NANOBIND BIG DNA KITS
Extract HMW DNA from a wide variety of sample types.
NANOBIND MAGNETIC DISKS
- Nanostructured surface binds DNA and protects it from shearing
- Extract high molecular weight (50–300+ kb) or ultra-high molecular weight (1+Mb) DNA
- Produce high extraction yields with high purity
RAPID BIND, WASH, AND ELUTE
- Process most sample types in only 1–4 hours
- Uses a single disk per tube
- Supports manual or automated processing
- No proprietary equipment required
DIVERSE SAMPLE TYPES ALL VALIDATED BY SEQUENCING
- Cultured cells and bacteria
- Blood
- Plants
- Tissues
- Developmental sample types include insects, fungal, and worm
NANOBIND KITS IN ACTION
NANOBIND
PUBLICATIONS
Read how scientists are using their projects. Sex chromosome transformation and the origin of a male-specific X chromosome in the creeping vole
HANDBOOKS
Nanobind handbooks were created as quick and easy reference guides to learn all about Nanobind kits and how they enable HMW DNA extraction.
APPLICATION NOTES
Nanobind application notes provide recommendations for hard-to-sequence sample types.
SHORT READ ELIMINATOR KITS
Remove short DNA from your sequencing samples
SRE SIZE SELECTION
- Deplete fragments from extracted DNA or from library
- Fast, easy, and inexpensive
- High recovery
SIMPLE SIZE SELECTIVE PRECIPITATION
- HMW DNA precipitated by centrifugation
- Low molecular weight (LMW) DNA is washed away
- Process many samples in parallel in 1 hour
- No proprietary equipment required
VARIABLE DEPLETION CUTOFF
- Progressive depletion begins at cutoff with depletion efficiency increasing as DNA gets shorter
- SRE XS depletes DNA <10 kb
- SRE depletes DNA <25 kb
- SRE XL depletes DNA <40 kb
SHORT READ ELIMINATOR IN ACTION
SRE handbooks
Short read eliminator resources provide insights into how to use SRE kits.