Circulomics Nanobind + SRE Sample Prep kits

Innovative solutions for high-molecular-weight (HMW) DNA sample prep

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END-TO-END WORKFLOWS FOR LONG-READ SEQUENCING AT SCALE

Extract the highest quality high molecular weight (HMW) DNA using Nanobind DNA extraction kits.

Enhance read lengths by depleting short DNA using SRE size selection kits.

Our experts offer end-to-end support from extraction through library prep and sequencing.

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“Our kits enable customers to

focus on science

rather than stress over sample prep.”

— Dr. Kelvin Liu, Founder and CEO of Circulomics

NANOBIND BIG DNA KITS

Extract HMW DNA from a wide variety of sample types.

NANOBIND MAGNETIC DISKS

  • Nanostructured surface binds DNA and protects it from shearing
  • Extract high molecular weight (50–300+ kb) or ultra-high molecular weight (1+Mb) DNA
  • Produce high extraction yields with high purity

RAPID BIND, WASH, AND ELUTE

  • Process most sample types in only 1–4 hours
  • Uses a single disk per tube
  • Supports manual or automated processing
  • No proprietary equipment required

DIVERSE SAMPLE TYPES ALL VALIDATED BY SEQUENCING

  • Cultured cells and bacteria
  • Blood
  • Plants
  • Tissues
  • Developmental sample types include insects, fungal, and worm

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NANOBIND KITS IN ACTION

HANDBOOKS

Nanobind handbooks were created as quick and easy reference guides to learn all about Nanobind kits and how they enable HMW DNA extraction.

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APPLICATION NOTES

Nanobind application notes provide recommendations for hard-to-sequence sample types.

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PROTOCOLS

Download protocols for hundreds of different sample types.

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EXPLORE

Did you know we have automated HMW DNA extraction scripts in development?

Explore resources

SHORT READ ELIMINATOR KITS

Remove short DNA from your sequencing samples

SRE SIZE SELECTION

  • Deplete fragments from extracted DNA or from library
  • Fast, easy, and inexpensive
  • High recovery

SIMPLE SIZE SELECTIVE PRECIPITATION

  • HMW DNA precipitated by centrifugation
  • Low molecular weight (LMW) DNA is washed away
  • Process many samples in parallel in 1 hour
  • No proprietary equipment required

VARIABLE DEPLETION CUTOFF

  • Progressive depletion begins at cutoff with depletion efficiency increasing as DNA gets shorter
  • SRE XS depletes DNA <10 kb
  • SRE depletes DNA <25 kb
  • SRE XL depletes DNA <40 kb

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SHORT READ ELIMINATOR IN ACTION

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SRE handbooks

Short read eliminator resources provide insights into how to use SRE kits.

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SRE publications

Real-life examples of what other scientists are doing.

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Talk with an expert

If you have a question, need to check the status of an order, or are interested in purchasing an instrument, we're here to help.