Blog
October 29, 2026
Sequencing 101: HiFi long-read analysis for clinical research workflows
Many clinical research genomics teams have built deep expertise around short-read analysis. They know how to assess data quality, align reads, call variants, weigh evidence, and connect genomic findings…
October 27, 2026
Recent epi-C publications from our users
The ability to detect DNA methylation with PacBio sequencing may be old news, but the scientific discoveries it enables are anything but. Since the inception of PacBio long-read sequencing,…
October 22, 2026
How certified service providers expand access to HiFi sequencing with SPRQ-Nx chemistry
A complete view of the genome often depends on the regions that are hardest to sequence. Structural variants, repeat expansions, and segmental duplications can shape disease risk, trait biology,…
October 15, 2026
New opportunities to streamline targeted sequencing workflows with PureTarget
Many genes central to human disease research sit in regions of the genome that are complex and difficult to sequence. Repeat expansions, genes with highly similar pseudogenes, and loci…
October 8, 2026
Harnessing the Kivvi tool to resolve the genetics of FSHD with HiFi sequencing
For families affected by facioscapulohumeral muscular dystrophy (FSHD), one of the hardest parts of the condition is not knowing what comes next. FSHD is one of the more common…
October 1, 2026
Powered by PacBio:
Selected publications from July – September 2026
This quarter’s publications point to a shared theme. Whether researchers are searching for clearer answers in rare disease, mapping cell identity across the human body, or interpreting variants linked…
September 24, 2026
How to build the scientific case that gets your grant funded
For researchers across all stages of their careers, grant funding decisions can often feel like a black box. Despite this ambiguity though, one thing that holds across the proposals…
September 17, 2026
2026 Metagenomics SMRT Grant Awardees
We are thrilled to announce the winners of the 2026 Metagenomics SMRT Grant for HiFi shotgun metagenomics. This year’s program received hundreds of amazing proposals from researchers around the…
September 10, 2026
How to build a more competitive grant proposal without losing your research time to it
Building a research program takes a career’s worth of scientific work. Writing the grant proposal to fund the next step asks for a different kind of effort entirely, and…
September 3, 2026
HiFi sequencing sets the benchmark for environmental health metabarcoding
Understanding biodiversity means knowing which species are present, in what abundance, and how those communities change over time or in response to disturbance. This question sits at the core…
August 27, 2026
Complete telomere-to-telomere genome assembly across the tree of life
For decades, reference genomes carried a hidden asterisk. Even the best assemblies contained gaps, particularly in regions packed with repetitive sequences, where short reads pile up but fail to…
August 20, 2026
SPRQ-Nx on Vega raises the bar for benchtop HiFi sequencing
PacBio began shipping SPRQ-Nx chemistry for the Vega system this week, a launch that meaningfully expands what benchtop HiFi sequencing can do. A companion software update arrives alongside it,…
August 17, 2026
Customer success story:
How Uppsala University and the Genome of Sweden project are scaling national genomics projects with Revio and SPRQ-Nx
When Dr. Adam Ameur first encountered long-read sequencing data, the idea of sequencing thousands of complete human genomes with long reads seemed distant. Back in 2013, he was using…
August 13, 2026
How long-read sequencing builds the foundation for AI-driven biopharma
Artificial intelligence is reshaping nearly every stage of drug discovery and development. From identifying new therapeutic targets to predicting protein function, designing therapeutics, and improving patient stratification, AI has…
August 10, 2026
Measuring – not guessing – the true path
Over the past ~15 years, several attempts were made to adapt short-read sequencing to capture longer-distance information, including 10X Genomics linked reads, Illumina TruSeq synthetic long reads, and Illumina…