This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

November 22, 2023  |  Human genetics research

Sequencing 101: Tandem repeats

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In the field of genetics, the concept of tandem repeats has been both scientifically fascinating, experimentally challenging, and motivating for technology development. As DNA sequencing technologies and analysis tools have…

November 9, 2023  |  Human genetics research

Capturing human genomic diversity

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A new Arab pangenome reference has been constructed from 43 individuals enabling the study of variants and sequences of significance to the Arab population. In a newly released preprint entitled…

June 29, 2023  |  Human genetics research

Population genomics isn’t ‘one-size-fits-all’

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Delve deeper into the importance of capturing diversity with population-specific reference pangenomes. The movement towards the development of pangenomes is gaining steam, bringing the reality of truly personalized medicine closer….

June 14, 2023  |  Human genetics research

A HiFi movement – reference pangenomes

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Fresh off the special Nature issue last month on the first human pangenome reference (featured in a previous blog), the first regional human pangenome reference study, entitled A Pangenome Reference…

May 18, 2023  |  Sequencing methods

Sequencing 101: Sequencing coverage

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This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…

April 20, 2023  |  Data analysis

VAMOS! Discover hidden VNTRs with long reads

See how the Chaisson lab created a new method to characterize human VNTR variation with PacBio long-read sequencing. Structural variants are hard to find with short-read sequencing methods At present,…

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