This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Cancer research depends on the details we can actually see. And, until now, FFPE samples have not been compatible with long-read sequencing. That’s changing. This year at AACR, we…
The complexities of cancer biology are famously tricky to decipher. Peering into the murky cancer genome and making sense of tumor mechanisms has long been the goal of researchers…
Cristian Tomasetti, PhD, discusses the positive impact of super-accurate PacBio short reads on the development of cancer early detection assays at TGen and City of Hope.
In the complex landscape of cancer biology, the exploration of microsatellite instability (MSI) has emerged as a promising frontier, offering potentially profound insights that could help improve diagnostic methodologies and…
When developing effective personalized immunotherapies, such as cancer vaccines, a pivotal factor lies in uncovering tumor neoantigens that can serve as crucial therapeutic targets. Traditionally, neoantigen discovery heavily relied on…
pbfusion is a new software tool for detecting gene fusions and other transcriptional abnormalities in PacBio Iso-Seq data. The advancement of cancer research depends on the ability to accurately detect…
Uncover the mysteries of RNA dysregulation in cancer Our understanding of the complex biology of cancers is currently limited by the sequencing technology that we have available. For example, a…
In this article, we discuss PacBio RNA sequencing through the lens of our most recent Iso-Seq Social club event. Read about the exciting scientific wins that were shared, and see…
At PacBio, we are driven to create the most sophisticated multiomic sequencing technologies so that you can forge a new frontier in cancer research. Through the SMRT Grant program, PacBio awards free…
Olga Anczukow (@OlgaAnczukow), PhD, a leading expert on breast cancer at the Jackson Laboratory, recently presented on how HiFi sequencing (PacBio’s highly accurate long-read sequencing technology) with the Iso-Seq method…
It’s Breast Cancer Awareness Month, and we can’t think of a better way to celebrate than to honor the passionate scientist who has perhaps single-handedly done more to advance breast…
Will the next big cancer breakthrough be in immunotherapy? Therapeutic modification of the tumor microenvironment or microbiome? Or early detection and screening? Whatever the result, long-read sequencing technology can play…
The PIK3CA oncogene has been the target of intense research scrutiny for decades. Remarkably, though, a new paper in Science today reports completely novel findings about compound mutations that are…
Variety is the spice of life, and one of the drivers of genetic variation is gene splicing. After a gene is transcribed, there are alternatively spliced transcripts that add even…
In an exciting paper that made the cover of Genome Research, scientists from Cold Spring Harbor Laboratory and collaborating institutions report the genome sequence and transcriptome of a commonly used…
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