This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
The ability to detect DNA methylation with PacBio sequencing may be old news, but the scientific discoveries it enables are anything but. Since the inception of PacBio long-read sequencing,…
Many genes central to human disease research sit in regions of the genome that are complex and difficult to sequence. Repeat expansions, genes with highly similar pseudogenes, and loci…
For clinical research laboratories evaluating long-read sequencing, the central question is often not whether longer reads are useful. The value is clearest in the places where conventional approaches have…
In genomics, every lab is chasing the same trio of workflow priorities: working toward results that are accurate, flexible in application, and efficient in practice. For labs focused on…
Genome editing technologies are transforming the development of next-generation therapeutics. From CRISPR-Cas systems to base and prime editors, these approaches offer unprecedented opportunities to correct disease-causing mutations and engineer…
In time-critical settings, like a neonatal intensive care unit, the pressure to find explanations is immediate. For example, an estimated 60% of level IV NICU infants in the US…
Sequencing has transformed our ability to study genetic variation across the tree of life, but DNA sequence alone does not explain how biological traits emerge. The same genome can…
Cancer is not driven by DNA sequence mutations alone. Chemical modifications layered onto DNA can reshape gene regulation without altering the underlying code, silencing tumor suppressors, activating oncogenes, and…
Oftentimes in biology, the biggest advances come from new ways of measuring complex systems, rather than a single discovery in itself. This publication spotlight highlights a recent Nature Biotechnology…
Epigenetics offers critical insight into how the genome is regulated beyond DNA sequence alone, shaping cellular identity, function, and disease. Along with our co-sponsor EpiCypher, we are excited to…
As genetics research evolves, scientists are recognizing that it’s not just the DNA sequence that matters, it’s how that DNA is packaged. The study of epigenetics, how chromatin structure…
In genome editing, precision is the goal, but biology has a way of introducing variation of its own. Genetic mosaicism occurs when different genetic variants coexist within the same…
As many as 7 in 10 people carry at least one pathogenic genetic variant, even if they have no family history of disease1. That means most couples could unknowingly…
Kinnex has been making a splash since the day it launched – showing up in talks, turning heads in RNA labs, and putting its use cases solidly in the…
We just wrapped up the European Society of Human Genetics (ESHG) Conference in Milan Italy, surrounded by researchers, collaborators, and a shared focus on the future of human genomics….
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