January 30, 2025 | Epigenetics
Sequencing 101: Epigenetics
Epigenetics is all about understanding how gene activity can change without altering the DNA sequence itself. Think of it as a “volume control” for your genes, turning them up…
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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
November 21, 2024 | Targeted sequencing
Gaining deeper insight with targeted sequencing
Big things are happening at PacBio! The latest launches of the Vega system and SPRQ chemistry are creating quite a buzz and we are eager to continue exploring the…
September 20, 2024 | RNA sequencing
RNA sequencing with Kinnex kits transforms University of Southampton rare disease research
Adopting new technologies in scientific research can feel like a leap of faith. But imagine if that leap opens the door for your lab to help provide answers for…
August 8, 2024 | Targeted sequencing
Breakthrough research: Characterizing degenerative repeat expansion disorders with PacBio PureTarget panel
In genomics, DNA is often compared to a cookbook, filled with recipes that guide the cells in your body. But where do tandem repeats fit into this analogy? Think…
June 27, 2024 | Sequencing methods
Going beyond the “needle in a haystack” with Onso short-read sequencing
We’re thrilled to have recently launched our summer promotions for Onso sequencing. These offers open the door for researchers to experience the incredible accuracy of Q40+ accuracy, at…
June 20, 2024 | RNA sequencing
Winning human RNA SMRT Grant proposals announced
If you had the chance, how would you elevate your human genomics research using highly-accurate full-length isoform-level sequencing? We posed that question to researchers in January with the…
April 25, 2024 | RNA sequencing
Kinnex in three acts: full-length RNA sequencing for human disease research
Alternative splicing occurs when exons from the same gene combine in different ways, resulting in different (but related) RNA transcript isoforms, which in turn create different proteins with distinct structures…
February 21, 2024 | RNA sequencing
Watch: Kinnex kits enable full-length 16S and RNA sequencing at scale
When new sequencing instruments are released, great leaps in genomics capabilities follow. But did you know that for some applications like 16S microbiome research, gene annotation, or cancer transcriptomics, “new-instrument-level” performance can be achieved with something as simple as an off-the-shelf kit?
December 12, 2023 | RNA sequencing
Kinnex launch promises to revolutionize RNA research
RNA sequencing (RNA-seq) has become an indispensable tool for analyzing transcriptomes across all domains of life that can reveal insights about biology and disease. While the genome remains relatively constant…
September 27, 2023 | Sequencing methods
Into the multiome: Four high-quality ‘omes from a single Revio SMRT Cell run
As Marvel superheroes traverse the multiverse to save the day, genomics researchers are our superheroes as they navigate the daunting multiverse that is biology. The complex and dynamic interactions between…
August 1, 2023 | Whole genome sequencing
Watch: A method for chromosome-level phasing of HiFi assemblies
As more researchers embrace the benefits of PacBio long-read sequencing technology, an expanding community of analysis tool developers has taken shape. Thanks to this growing excitement around PacBio capabilities there…
July 28, 2023 | RNA sequencing
A HiFi movement: Isoform-resolved cell atlases
Cellular cartography has been just as important for biologists to navigate the complex topography of living systems as was the mapping of the earth’s landscapes for explorers hundreds of years…
May 18, 2023 | Sequencing methods
Sequencing 101: Sequencing coverage
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…
November 1, 2022 | Human genetics research
Innovations abound at Iso-Seq Social Club 3
In this article, we discuss PacBio RNA sequencing through the lens of our most recent Iso-Seq Social club event. Read about the exciting scientific wins that were shared, and see…
October 31, 2022 | HiFi difference
The HiFi difference Halloween edition – DEAD GENES
Pseudogenes are typically regarded as non-functional DNA elements, and have therefore not received as much attention as their parent genes. Thanks to PacBio HiFi sequencing, many pseudogenes now RISE FROM…
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