This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Over the past ~15 years, several attempts were made to adapt short-read sequencing to capture longer-distance information, including 10X Genomics linked reads, Illumina TruSeq synthetic long reads, and Illumina…
Genomic testing has historically evolved around limitations. Different technologies were developed to answer different questions, and over time, laboratories built workflows that stitched those answers together. The result is…
By Samantha Kalla, Field Application Scientist, PacBio For years, five variables have defined the trade-offs in sequencing: read length, accuracy, methylation, cost, and sample input. Pick long reads, accept…
In cancer genomics, assumptions have a short shelf life. Not long ago we published a blog series debunking several common myths about long-read sequencing. At the time, many of…
Cell and gene therapy research is crucial for biopharma development, with HiFi long-read sequencing significantly enhancing many sequencing applications throughout the process. Even though AAV sequencing is one of…
The organisms you study might be tiny, but the importance of the work you do is anything but. PacBio HiFi sequencing brings the microscopic world into sharp focus, offering…
The world is moving at a fast pace, isn’t it? Climate shifts, growing populations, and changing ecosystems are stacking up some serious challenges for species all over the planet, including…
The complexities of cancer biology are famously tricky to decipher. Peering into the murky cancer genome and making sense of tumor mechanisms has long been the goal of researchers…
Hearing “the end of the beginning” or “the dawn of a new era” might sound like a grandiose way to describe a scientific milestone. Would it surprise you to…
In the fast-evolving landscape of genomics, the pace can be dizzying, and the fear of falling behind is real. Genomic research undergoes constant change, so if you want to…
The books of life are fascinating yet challenging reads, owing to the complexity of the underlying biological processes and their alterations that lead to disease. Thanks to highly accurate HiFi…
A new preprint entitled Utility of long-read sequencing for All of Us – from research groups at Baylor College of Medicine, the Broad Institute, Jackson Laboratory, Discovery Life Sciences, Harvard…
This year, the scientific community has achieved many “firsts” – across genomes, transcriptomes, epigenomes, metagenomes, and more – with long and accurate HiFi sequencing. Another, seasonally timely, “first” was just…
Antibodies are the work horses of the adaptive immune system, identifying and neutralizing foreign objects like bacteria and viruses, and thereby are central to the science of immunology. A new…
Pseudogenes are typically regarded as non-functional DNA elements, and have therefore not received as much attention as their parent genes. Thanks to PacBio HiFi sequencing, many pseudogenes now RISE FROM…
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