Microbial genomics

See the microbial world in high resolution

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MICROBIAL GENOMICS SOLUTIONS

PUBLIC HEALTH + SURVEILLANCE

Protect public health with comprehensive genomic surveillance solutions that deliver the complete information you need for accurate characterization and tracking of all pathogens circulating in the community.

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INFECTIOUS DISEASE + MICROBIOLOGY RESEARCH

Advance human health with new insights into the viruses, bacteria, and protozoa that cause infectious disease. Reveal the biology of host-pathogen dynamics, drug resistance, and immune escape.

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DISCOVERY AND INDUSTRIAL MICROBIOLOGY

Address the global need for novel therapeutics, environmental remediation, and efficient chemical production by mining even the most difficult to sequence microbial genomes and complex microbial communities.

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PLANT AND ANIMAL MICROBIOLOGY

Explore the biology of microbial symbionts, pathogens, microbiomes and phytobiomes and the roles they play in crop yields, livestock health, and the preservation of wild animals and natural habitats.

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SETTING A NEW STANDARD FOR MICROBIAL SEQUENCING

Microbes account for most of the diversity of life on our planet, yet fewer than 1% have been identified. To understand this ever-evolving world, scientists need the unbiased, accurate, and comprehensive information that only PacBio long-read sequencing can provide.

Targeted - amplicon Targeted - enrichment Whole genome sequencing Metagenome sequencing
COVID-19 and virus sequencing
Microbiology research
Infectious disease research
Industrial microbiology
Plant + animal microbiology
Healthcare associated infections
Foodbourne pathogens
Microbiome

MICROBIAL GENOMICS IN ACTION

REVEAL MICROBIAL DIVERSITY WITH FULL-LENGTH 16S SEQUENCING

PacBio full-length 16S data delivers species-resolved information that would otherwise…

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HIFI METAGENOMICS: RICHER DATA, MORE MAGS, NEW INSIGHTS

Deep sequencing that combines HiFi reads and Hi-C data can enormously increase recovery of high…

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INTRODUCING THE HIFIVIRAL FOR SARS-COV-2 KIT

The HiFiViral SARS-CoV-2 kit supports labs working on the front line of the COVID-19…

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EXPLORE

Did you know we have a comprehensive library of reports, papers, and videos related to microbial genomics?

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SHAPING THE FUTURE

FUTURE-PROOF YOUR LAB — COVID-19 SURVEILLANCE WITH THE HIFIVIRAL SARS-CoV-2 KIT

Recent Omicron sequencing data shows how the HiFiViral kit can help your lab avoid SARS-CoV-2 surveillance disruptions when new variants arise while saving on time, labor and plastics.

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Flexible and scalable HiFi sequencing for microbial genomics research

HiFi sequencing applications give researchers more complete and detailed information about microbial genomes, spurring new insights into host-pathogen dynamics, microbial evolution and adaptation, and critical traits including drug resistance, infectivity, and virulence.

Track the evolution of viral populations

Achieve accurate surveillance of viral populations in a host, within a community, or across geographic regions by phasing entire viral genes or genomes.

Resolve bacterial strains, serotypes, and plasmids

Track pathogen outbreaks in humans, plants, and animals through food systems, hospitals, and communities with affordable, high throughput, high quality whole genome sequencing.

Improve gene discovery

Obtain improved gene discovery with reliably closed highly accurate bacterial genomes.

Correlate specific species

Distinguish community composition at the strain level to correlate specific species to difference in metagenome function or systemic outcomes.

Connect metagenome community functions

Use closed and high-quality MAGs to align metagenome community functions to specific strains.

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The power of HiFi Sequencing for metagenome assembly

One way to improve assembly completeness and contiguity is to use long-read sequencing. However, not all long reads are the same. Did you know that once read lengths are longer than most of the repeats in a genome or metagenome, incremental gains in raw read accuracy improve assemblies faster than higher coverage or even large gains in read length?

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APPLICATIONS TO FUEL MICROBIOLOGY AND INFECTIOUS DISEASE RESEARCH

MICROBIAL WHOLE GENOME SEQUENCING

Learn how affordable it is to upgrade your draft-quality microbial whole genome sequencing pipeline to consistently produce closed, reference-quality genomes.

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VIRUS SEQUENCING

Explore the easy to use, robust, and scalable kitted solution for SARS-CoV-2 sequencing.

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METAGENOME SEQUENCING AND ASSEMBLY

Overcome the challenge of distinguishing reads from closely related strains in a metagenome sample with long, highly accurate HiFi reads, yielding more and higher quality MAGs than what can be achieved with other technologies.

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BENEFITS OF MICROBIAL SEQUENCING

TRACK THE SPREAD AND TRAITS OF PATHOGENS

Scientists in commercial, academic, and government research teams are using highly accurate HiFi sequencing data to resolve variants of the SARS-CoV-2 virus that exist within one individual or across a cohort, which is critical to developing and maintaining effective diagnostics, vaccines, and therapeutics.

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Accelerate discovery

ACCELERATE DISCOVERY AND ADVANCE RESEARCH

PacBio allows microbiology researchers to fully characterize microbial organisms, dissect complex microbial communities, and identify emerging pathogens with high accuracy enabling scientists around the world to accelerate discovery, advance research, and protect human, animal, and environmental health.

Microbial whole genome sequencing best practices

Metagenomic sequencing best practices guide

HiFiViral best practices guide

IDENTIFY AND TRACK ANTIMICROBIAL RESISTANCE TO IMPROVE HUMAN HEALTH

Antimicrobial resistance (AMR) is a global health concern and is a significant threat to human and animal health. PacBio sequencing can identify strain characteristics, AMR genes, and mobile vectors mediating the spread of drug resistance.

Hoffman et al. (2014) Comparative genomic analysis and virulence differences in closely related Salmonella enterica serotype Heidelberge isolates from humans, retail meats and animals. Genome Biol Evol. 6(5),1046–1068

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CONNECTING THE MICROBIOME TO OUTCOMES IN HUMAN HEALTH

The microbiome comprises trillions of microorganisms living on and inside each of us. PacBio is helping scientists unravel the complex interplay between microbiomes and the full scope of its potential for treating disease and promoting health.

Ashby, Meredith and Ma, Bing and Weinstock, George (2020) Webinar: A HiFi View — Sequencing the gut microbiome with highly accurate long reads

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