This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
For decades, reference genomes carried a hidden asterisk. Even the best assemblies contained gaps, particularly in regions packed with repetitive sequences, where short reads pile up but fail to…
In time-critical settings, like a neonatal intensive care unit, the pressure to find explanations is immediate. For example, an estimated 60% of level IV NICU infants in the US…
For clinical laboratories evaluating long-read sequencing, the central question has changed. A substantial and growing body of research now demonstrates that HiFi sequencing can deliver the accuracy, comprehensiveness, and…
Many researchers find that the sequencing problems they run into are not really problems with the sequencing itself. More often, they trace back to earlier decisions about how an…
Genomic testing has historically evolved around limitations. Different technologies were developed to answer different questions, and over time, laboratories built workflows that stitched those answers together. The result is…
By Samantha Kalla, Field Application Scientist, PacBio For years, five variables have defined the trade-offs in sequencing: read length, accuracy, methylation, cost, and sample input. Pick long reads, accept…
Oftentimes in biology, the biggest advances come from new ways of measuring complex systems, rather than a single discovery in itself. This publication spotlight highlights a recent Nature Biotechnology…
It’s 2026 and there’s no better time than now to look back at 2025 and celebrate its meaningful impact in genomics. In 2025, PacBio focused on driving technical advances,…
The challenges of bringing on new technology feel surprisingly similar regardless of career stage or field. Grad students, bioinformaticians, PIs, and professionals running core facilities all want to make…
The coffee’s cold, your pipette tips are backordered, and someone just booked your favorite lab bench. Science can be full of small annoyances. We can’t solve them all, but…
Thanks to SPRQ chemistry and the Ampli-Fi protocol, researchers are now unlocking whole genomes from one of the most notoriously tricky sample types: dried blood spots (DBS). Collected from…
At PacBio, we’re celebrating DNA Day with excitement and appreciation—not just for what DNA is, but for how far we’ve come in decoding it. Each year on April 25,…
What happens when one of the world’s top genomics service providers gets their hands on cutting-edge chemistry? Big things. At Signios Biosciences, innovation is the engine that drives powerful…
The new SPRQ chemistry for the Revio system is making high-quality long-read sequencing more efficient than ever—delivering more data from less input without compromising accuracy or cost efficiency. But…
The first benchtop HiFi long-read sequencing platform is now here with Vega, named after one of the brightest stars in the sky. This exciting platform builds out the…
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