This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
For many genetics labs, the road from instrument installation to routine use consists of long months of validation, workflow development, and institutional sign-off. Dr. Claire Guissart, head of the…
We are excited to share highlights from the 2026 APAC PRISM event, held this year in Fukuoka, Japan. Located near Canal City, this PRISM event offered attendees the opportunity…
For clinical research laboratories evaluating long-read sequencing, the central question is often not whether longer reads are useful. The value is clearest in the places where conventional approaches have…
Cancer genomics is one of the most complex and consequential areas in all of life sciences. The genetic and epigenetic changes that drive tumor development, progression, and treatment resistance…
In genomics, every lab is chasing the same trio of workflow priorities: working toward results that are accurate, flexible in application, and efficient in practice. For labs focused on…
Genome editing technologies are transforming the development of next-generation therapeutics. From CRISPR-Cas systems to base and prime editors, these approaches offer unprecedented opportunities to correct disease-causing mutations and engineer…
This quarter’s publications are showing us where genomics is headed: from incomplete views of the genome toward comprehensive, genome-wide analysis. Across population genomics, clinical whole-genome sequencing, and medical genetics,…
In time-critical settings, like a neonatal intensive care unit, the pressure to find explanations is immediate. For example, an estimated 60% of level IV NICU infants in the US…
Sequencing has transformed our ability to study genetic variation across the tree of life, but DNA sequence alone does not explain how biological traits emerge. The same genome can…
For clinical laboratories evaluating long-read sequencing, the central question has changed. A substantial and growing body of research now demonstrates that HiFi sequencing can deliver the accuracy, comprehensiveness, and…
Microbes account for most of the diversity of life on our planet, yet fewer than 1% have been identified. They drive human health and disease, shape agriculture, cycle nutrients…
Many researchers find that the sequencing problems they run into are not really problems with the sequencing itself. More often, they trace back to earlier decisions about how an…
For couples experiencing recurrent pregnancy loss or difficulty conceiving, the search for answers can become an exhausting and painful journey. Many spend years moving through appointments, tests, and inconclusive…
Genomic testing has historically evolved around limitations. Different technologies were developed to answer different questions, and over time, laboratories built workflows that stitched those answers together. The result is…
By Samantha Kalla, Field Application Scientist, PacBio For years, five variables have defined the trade-offs in sequencing: read length, accuracy, methylation, cost, and sample input. Pick long reads, accept…
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