This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
This quarter’s publications point to a shared theme. Whether researchers are searching for clearer answers in rare disease, mapping cell identity across the human body, or interpreting variants linked…
For researchers across all stages of their careers, grant funding decisions can often feel like a black box. Despite this ambiguity though, one thing that holds across the proposals…
We are thrilled to announce the winners of the 2026 Metagenomics SMRT Grant for HiFi shotgun metagenomics. This year’s program received hundreds of amazing proposals from researchers around the…
Building a research program takes a career’s worth of scientific work. Writing the grant proposal to fund the next step asks for a different kind of effort entirely, and…
Understanding biodiversity means knowing which species are present, in what abundance, and how those communities change over time or in response to disturbance. This question sits at the core…
For decades, reference genomes carried a hidden asterisk. Even the best assemblies contained gaps, particularly in regions packed with repetitive sequences, where short reads pile up but fail to…
PacBio began shipping SPRQ-Nx chemistry for the Vega system this week, a launch that meaningfully expands what benchtop HiFi sequencing can do. A companion software update arrives alongside it,…
When Dr. Adam Ameur first encountered long-read sequencing data, the idea of sequencing thousands of complete human genomes with long reads seemed distant. Back in 2013, he was using…
Artificial intelligence is reshaping nearly every stage of drug discovery and development. From identifying new therapeutic targets to predicting protein function, designing therapeutics, and improving patient stratification, AI has…
Over the past ~15 years, several attempts were made to adapt short-read sequencing to capture longer-distance information, including 10X Genomics linked reads, Illumina TruSeq synthetic long reads, and Illumina…
For many genetics labs, the road from instrument installation to routine use consists of long months of validation, workflow development, and institutional sign-off. Dr. Claire Guissart, head of the…
We are excited to share highlights from the 2026 APAC PRISM event, held this year in Fukuoka, Japan. Located near Canal City, this PRISM event offered attendees the opportunity…
For clinical research laboratories evaluating long-read sequencing, the central question is often not whether longer reads are useful. The value is clearest in the places where conventional approaches have…
Cancer genomics is one of the most complex and consequential areas in all of life sciences. The genetic and epigenetic changes that drive tumor development, progression, and treatment resistance…
In genomics, every lab is chasing the same trio of workflow priorities: working toward results that are accurate, flexible in application, and efficient in practice. For labs focused on…
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