This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Genomic testing has historically evolved around limitations. Different technologies were developed to answer different questions, and over time, laboratories built workflows that stitched those answers together. The result is…
By Samantha Kalla, Field Application Scientist, PacBio For years, five variables have defined the trade-offs in sequencing: read length, accuracy, methylation, cost, and sample input. Pick long reads, accept…
Scientists rely on HiFi long-read sequencing for one reason above all else: it delivers highly accurate, information-rich sequence data needed to answer complex biological questions. That quality is driven…
Earth Day is a reminder that life on this planet is as intricate as it is interconnected. From coral reefs to crop fields, every ecosystem tells a story written…
Today’s cancer drug development has evolved far beyond traditional chemotherapies. Curre oncology pipeline includes precision small molecules, monoclonal antibodies, antibody-drug conjugates (ADCs), CAR-T therapies, TCR-engineered cells, and personalized cancer…
There is a moment that many patients and families know too well. It often starts with uncertainty, followed by a series of appointments, blood draws, and test results that…
Cancer is often described as a disease of the genome, but this underlying biology introduces layers of complexity. Some cancer variants are inherited, whereas others emerge over time. Several…
Our latest roundup highlights the diverse ways researchers are using PacBio HiFi sequencing to uncover new insights across rare disease, cancer, and transcriptomics. The year has started strongly, with…
Basecamp Research’s recent selection of PacBio HiFi sequencing to support its Trillion Gene Atlas initiative highlights an important shift in biological AI: the future will not be shaped by…
Accurately capturing immune diversity is critical to advancing our understanding of disease mechanisms and enabling the development of more precise and effective therapies. However, conventional immune profiling technologies lack…
In cancer genomics, assumptions have a short shelf life. Not long ago we published a blog series debunking several common myths about long-read sequencing. At the time, many of…
Cancer is not driven by DNA sequence mutations alone. Chemical modifications layered onto DNA can reshape gene regulation without altering the underlying code, silencing tumor suppressors, activating oncogenes, and…
We’ve loved sharing the Beyond the Bench series with audiences this year. So far, we’re hearing from viewers how much they value seeing the human side of genomics, and…
This rare disease month, we’ve explored the power of telling families’ stories and the impact of adopting HiFi sequencing in real-world settings. Each perspective is a valuable piece of…
When you work in rare disease, you recognize the pattern: Test. Wait. Repeat. For families, that loop is a stretch of time that includes birthdays, school years, and treatment…
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