This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
In time-critical settings, like a neonatal intensive care unit, the pressure to find explanations is immediate. For example, an estimated 60% of level IV NICU infants in the US…
Sequencing has transformed our ability to study genetic variation across the tree of life, but DNA sequence alone does not explain how biological traits emerge. The same genome can…
For clinical laboratories evaluating long-read sequencing, the central question has changed. A substantial and growing body of research now demonstrates that HiFi sequencing can deliver the accuracy, comprehensiveness, and…
Microbes account for most of the diversity of life on our planet, yet fewer than 1% have been identified. They drive human health and disease, shape agriculture, cycle nutrients…
Many researchers find that the sequencing problems they run into are not really problems with the sequencing itself. More often, they trace back to earlier decisions about how an…
For couples experiencing recurrent pregnancy loss or difficulty conceiving, the search for answers can become an exhausting and painful journey. Many spend years moving through appointments, tests, and inconclusive…
Genomic testing has historically evolved around limitations. Different technologies were developed to answer different questions, and over time, laboratories built workflows that stitched those answers together. The result is…
By Samantha Kalla, Field Application Scientist, PacBio For years, five variables have defined the trade-offs in sequencing: read length, accuracy, methylation, cost, and sample input. Pick long reads, accept…
Scientists rely on HiFi long-read sequencing for one reason above all else: it delivers highly accurate, information-rich sequence data needed to answer complex biological questions. That quality is driven…
Earth Day is a reminder that life on this planet is as intricate as it is interconnected. From coral reefs to crop fields, every ecosystem tells a story written…
Today’s cancer drug development has evolved far beyond traditional chemotherapies. Curre oncology pipeline includes precision small molecules, monoclonal antibodies, antibody-drug conjugates (ADCs), CAR-T therapies, TCR-engineered cells, and personalized cancer…
There is a moment that many patients and families know too well. It often starts with uncertainty, followed by a series of appointments, blood draws, and test results that…
Cancer is often described as a disease of the genome, but this underlying biology introduces layers of complexity. Some cancer variants are inherited, whereas others emerge over time. Several…
Our latest roundup highlights the diverse ways researchers are using PacBio HiFi sequencing to uncover new insights across rare disease, cancer, and transcriptomics. The year has started strongly, with…
Basecamp Research’s recent selection of PacBio HiFi sequencing to support its Trillion Gene Atlas initiative highlights an important shift in biological AI: the future will not be shaped by…
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