Sequencing systems

Access some of the world’s most advanced sequencing technologies.

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Introduction to PacBio sequencing systems

Building on years of cutting-edge research and development, our systems enable researchers to make discoveries that will change the world. Explore the exceptional accuracy of our long-read and short-read sequencing systems.

Revio systemREVIO SYSTEM
Long-read sequencing

Highly accurate HiFi sequencing for more complete views of genomes, epigenomes, and transcriptomes

Throughput to run up to 1,300 human HiFi genomes per year

Smart consumables for simple handling and less plastic waste

Powerful compute with Google Health DeepConsensus onboard

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Short-read sequencing

Up to 15x higher accuracy than other benchtop sequencers

Reduced requirement for sequencing coverage depth versus SBS sequencers

Resolve homopolymer and difficult to sequence regions

Low duplication rate, negligible index hopping

Rapid conversion of existing P5/P7 libraries for sequencing on the Onso system

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Long-read sequencing

Long, accurate HiFi reads with DNA methylation direct from the instrument in every run

Supports a wide range of applications – targeted sequencing, RNA sequencing, and whole-genome sequencing

Throughput match for microbial genome sequencing, AAV vector sequencing, Iso-Seq method, and more

Featured in hundreds of peer-reviewed publications

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“Using PacBio sequencing we can detect mutations that otherwise would be missed in Illumina sequencing”

– van Schendel, NAR Genomics and Bioinformatics, 2022
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Meet Revio and Onso — Our newest long-read and short-read sequencing systems. Long reads at a lower cost and higher throughput. Short reads with exceptional accuracy. Endless opportunities for discovery.

Your moment is waiting. What will you find?

Revio system   Onso system

Sequencing in action

Image depicting how SBB chemistry works showing nucleotides

SBB sequencing

The accuracy of SBB has the potential to advance cancer research, and broadly enable translational applications where sequencing quality is critical for unlocking new discoveries.

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The T2T Consortium recently accomplished a landmark achievement by generating a complete human genome for the very first time — all with the help of PacBio HiFi sequencing.

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Ladybug on a green leaf

How far we’ve come part one: insect genomics

The Sequel II and IIe platforms benefit entomologists even further by facilitating the sequencing of even the smallest species with as little as 5 ng of genomic DNA.

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PacBio has over 10,000 articles, reports, papers, and videos related to genomic sequencing

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