Blog
February 5, 2026
How SPRQ-Nx enables affordable long-read whole genome sequencing without added complexity
Long-read whole genome sequencing is starting to show up in places it rarely could before. With the introduction of SPRQ-Nx, HiFi sequencing has now become the most affordable long-read…
January 29, 2026
Beyond the Bench: Advancing cancer transcriptomics with HiFi long-read RNA sequencing
With the PacBio Beyond the Bench video series now live, we’re feeling the enthusiasm surrounding a personal look at scientists’ lives and the rituals that anchor their work. This…
January 22, 2026
Publication spotlight: HiFi sequencing enables haplotype-specific chromatin mapping from single cells using DAF-seq
Oftentimes in biology, the biggest advances come from new ways of measuring complex systems, rather than a single discovery in itself. This publication spotlight highlights a recent Nature Biotechnology…
January 15, 2026
2025 Epigenetics SMRT Grant Awardees
Epigenetics offers critical insight into how the genome is regulated beyond DNA sequence alone, shaping cellular identity, function, and disease. Along with our co-sponsor EpiCypher, we are excited to…
January 9, 2026
A year in review: HiFi in the Headline
It’s 2026 and there’s no better time than now to look back at 2025 and celebrate its meaningful impact in genomics. In 2025, PacBio focused on driving technical advances,…
December 23, 2025
Meet the winners of the 2025 long-read low-pass SMRT Grant for plant and animal sciences
As we head into the holiday season, we are more excited than ever to share some good news by announcing the winners of the 2025 Long-read Low-pass SMRT Grant…
December 18, 2025
Beyond the Bench:
A series celebrating the people behind scientific progress
When the lights turn on in a genomics lab, the day is already in motion. Boxes of samples wait to be logged, barcodes are scanned, concentrations get double-checked and…
December 11, 2025
Sequencing 101: A long-read sequencing starter guide for every career stage
The challenges of bringing on new technology feel surprisingly similar regardless of career stage or field. Grad students, bioinformaticians, PIs, and professionals running core facilities all want to make…
December 4, 2025
Powered by PacBio:
Selected publications from November 2025
November’s standout publications show how PacBio technology is impacting advances in human genomics research. This month’s selection includes studies on accurate variant detection in paralogous genes, a new visualization…
November 26, 2025
How long-read sequencing informs the future of food from genome to table
Thanksgiving is almost here, and we’re filled with gratitude for the food on our tables and the science that helps make this possible. From the corn in a casserole…
November 24, 2025
Publication spotlight:
First major study from the HiFi Solves EMEA consortium showcases the potential clinical power of a HiFi genome
We just got back from the Molecular Pathology (AMP) conference in Boston, where the conversation around clinical research and translational genomics was in full motion. The field is moving…
November 13, 2025
How pairing EpiCypher’s Fiber-seq with HiFi sequencing delivers an all-in-one multiomic view
As genetics research evolves, scientists are recognizing that it’s not just the DNA sequence that matters, it’s how that DNA is packaged. The study of epigenetics, how chromatin structure…
November 7, 2025
Powered by PacBio:
Selected publications from October 2025
This month’s roundup showcases the diverse ways researchers are using PacBio technology to uncover new insights across population genomics, cancer research, neurodegenerative disease, and precision medicine. In the October…
October 30, 2025
Publication spotlight:
Capturing the full picture of genome editing with custom PureTarget panels
In genome editing, precision is the goal, but biology has a way of introducing variation of its own. Genetic mosaicism occurs when different genetic variants coexist within the same…
October 22, 2025
Customer success story:
How two University of Michigan cores use HiFi sequencing to cut costs, save time, and improve accuracy in transgenic models
At the University of Michigan, two cores on opposite sides of campus are working together to change what’s possible in genomics. Judith Meyers helps run the Advanced Genomics Core…