Review of several AGBT presentations including, Eric Antoniou and Mike Schatz from Cold Spring Harbor Laboratory, Eric Schadt from Mt. Sinai and PacBio CSO Jonas Korlach.
Scientists from Virginia Bioinformatics Institute and Baylor College of Medicine are using long reads from the PacBio RS to sequence through repeat structures in the human genome
For the first time, researchers sequenced DNA molecules without the need for the standard pre-sequencing workflow known as library preparation.
Long read sequencers combine with short read sequencers for better results in complex genome assembly and finishing.
New sequencing kits increase average read lengths to more than 4,300 bases and increase throughput to between 200 and 250 megabases per SMRT cell.
Washington University Pediatric Cancer Genome Project discovery provides insight into a tough-to-cure form of acute myeloid leukemia that lays the groundwork for clinical care advances
Eric Schadt and colleagues at Mount Sinai School of Medicine and Harvard Medical School have used SMRT DNA sequencing to determine mechanisms of gene regulation in the E. coli bacteria
Looking for new methods to validate next-generation sequencing results, researchers at the Broad Institute have turned to the PacBio RSto validate human sequence data from Illumina runs.
BGI analyzed the advantages and disadvantages of all of the major DNA sequencing platforms.
Adam Phillippy explains how he and his colleague Sergey Koren developed an algorithm to help generate more accurate sequences using the PacBio RS
Broad Institute researchers share a new method of combining short reads and long reads generated on the PacBio RSthat is well-suited for de novo assembly and finishing of bacterial genomes.
Two new papers in Nature Biotechnology demonstrate the value of combining long reads from the PacBio RSwith the high-throughput, shorter “2nd-generation” read lengths.
Lenn Pennachio explains how the Joint Genome Institute (JGI) has devoted one of its PacBio RSsystems to genome finishing, while the other is used for epigenetics.
The Delaware Biotechnology Institute (DBI) at the University of Delaware (UD) have plans to use the PacBio RSDNA sequencing machine to conduct environmental and agricultural studies
A sequencing study led by UCSF has taken advantage of the PacBio RS‘s long reads to validate the disputed potential of internal tandem duplication mutations in the FLT3 gene as a therapeutic target in acute myeloid leukemia.
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