Researchers have sequenced and de novo assembled the Drosophila melanogaster genome on the PacBio RS II – the first time an animal genome has been sequenced and assembled solely with PacBio technology – and have produced a genome with fewer gaps and longer contigs than the current reference.
SMRT Sequencing technology is helping provide insight into FragileX syndrome, a research area that Dr. Paul Hagerman at the UC Davis School of Medicine has passionately been working to develop a diagnostic test for in the future.
Researchers from UCSD have developed a sequencing method using the PacBio RS to identify breakpoints for structural variations, which they think may eventually have applications in cancer, including early diagnosis and monitoring patients’ response to treatment.
Short sequencing reads obtained by RNA-seq offer precise counts of expressed transcripts, but no information on their structures. Now, researchers report a new approach using circular cDNA templates and PacBio long sequencing reads that enables quantitation of transcript isoforms.
Last week, Pacific Biosciences entered into an agreement with Roche Diagnostics to develop a sequencing system and assays for clinical diagnostics using its single-molecule real-time sequencing technology in a deal worth up to $75 million.
New England Biolabs has been using Pacific Biosciences’ RS machine to sequence bacterial genomes and study bacterial methylomes.
Researchers at McGill University have developed two different protocols for sequencing bacterial genomes in under 24 hours to monitor outbreaks.
Technology feature describes how recent advances in high-throughput sequencing are accelerating genomics research, but crucial gaps in data remain.
The 100K Genome Project has added 20 newly completed genome sequences of foodborne pathogens to NCBI’s database generated using Pacific Biosciences’ single-molecule sequencing technology.
Nobel Laureate Rich Roberts from New England Biolabs discusses his experience with SMRT Sequencing.
The 100K Genome Project today announced that it has added 20 newly completed genome sequences of foodborne disease-causing microorganisms to its public database at the National Center for Biotechnology Information.
A new technique could soon spur unprecedented insight into the role of bacterial epigenetics in the evolution of pathogen virulence.
Scientists from DOE JGI, PacBio and UW collaborate to develop a fully automated process from DNA sample preparation to the determination of the finished genome.
Long-read sequencing and Pacific Biosciences are back on the radar after the Advances in Genome Biology & Technology (AGBT) meeting in February in Marco Island, Florida.
In a revival of the era of finished genomes, scientists are using the long reads offered by sequencing technologies to close gaps in genome assemblies.
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