Quality Statement

Pacific Biosciences is committed to providing high-quality products that meet customer expectations and comply with regulations. We will achieve these goals by adhering to and maintaining an effective quality-management system designed to ensure product quality, performance, and safety.


Image Use Agreement

By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. If you do not agree to such terms, do not download, copy or use the images in any way, unless you have written permission signed by an authorized Pacific Biosciences representative.

Subject to the terms of this Agreement and the terms provided on the Legal Notices webpage (to the extent they do not conflict with the terms of this Agreement), you may use the images on the Site solely for (a) editorial use by press and/or industry analysts, (b) in connection with a normal, peer-reviewed, scientific publication, book or presentation, or the like. You may not alter or modify any image, in whole or in part, for any reason. You may not use any image in a manner that misrepresents the associated Pacific Biosciences product, service or technology or any associated characteristics, data, or properties thereof. You also may not use any image in a manner that denotes some representation or warranty (express, implied or statutory) from Pacific Biosciences of the product, service or technology. The rights granted by this Agreement are personal to you and are not transferable by you to another party.

You, and not Pacific Biosciences, are responsible for your use of the images. You acknowledge and agree that any misuse of the images or breach of this Agreement will cause Pacific Biosciences irreparable harm. Pacific Biosciences is either an owner or licensee of the image, and not an agent for the owner. You agree to give Pacific Biosciences a credit line as follows: "Courtesy of Pacific Biosciences of California, Inc., Menlo Park, CA, USA" and also include any other credits or acknowledgments noted by Pacific Biosciences. You must include any copyright notice originally included with the images on all copies.


You agree that Pacific Biosciences may terminate your access to and use of the images located on the PacificBiosciences.com website at any time and without prior notice, if it considers you to have violated any of the terms of this Image Use Agreement. You agree to indemnify, defend and hold harmless Pacific Biosciences, its officers, directors, employees, agents, licensors, suppliers and any third party information providers to the Site from and against all losses, expenses, damages and costs, including reasonable attorneys' fees, resulting from any violation by you of the terms of this Image Use Agreement or Pacific Biosciences' termination of your access to or use of the Site. Termination will not affect Pacific Biosciences' rights or your obligations which accrued before the termination.

I have read and understand, and agree to, the Image Usage Agreement.

I disagree and would like to return to the Pacific Biosciences home page.

Pacific Biosciences

The Most Wonderful Webinars of the Year

Thursday, December 31, 2020

The year the world went virtual is virtually over, so what better time to reflect on all the great online offerings featuring SMRT Sequencing this year. While we would have rather gathered in exotic locales to see you in person and share our science, 2020 did provide some amazing opportunities to go global and broadcast worldwide. 

Here are some of the highlights:


Sequencing 101: How Long-Read Sequencing Improves Access to Genetic Information

What better place to start than with an introduction to our technology, followed by a panel of sequencing experts — Melissa Laird-Smith (@SmithLab_UofL), Michael Hartigan, and Olga Vinnere Pettersson (@OlgaVPettersson) — with some sequencing basics: explaining long reads and their utility, how PacBio long-read sequencing differs from other technologies, and the applications PacBio offers and how they can benefit scientific research.



PacBio Global Summit

Our popular regional user group gatherings were combined into one mega meeting this year, which meant nearly 30 hours of talks across time zones, over the course of two days. With so many sessions, it’s impossible to cover them all here, but suffice it to say, there were many magnificent presentations by our users, plus hands-on workshops, live Q&As, and a meet-and-greet with our new CEO, Christian Henry. Well worth spending time catching up!

Register here to watch these presentations on-demand


Plant and Animal Genomics (PAG) Conference 

We rang in 2020 at the ever-popular PAG meeting. In addition to an overview of the year ahead by CSO Jonas Korlach, our workshop featured several great talks by our users, including an update on the Sanger Institute’s Darwin Tree of Life project by Mark Blaxter (@blaxterlab); a talk about the tetraploid rose assembly by Bart Nijland (@bart3601) of Genetwister Technologies; great apes work by Zev Kronenberg (@zevkronenberg); and a discussion of plant-living funghi by Jana U’Ren (@you_wren) of the University of Arizona.

Missing PAG 2021 in January? Join us for PAGBio Day, our online alternative, on Jan. 19. Save your seat!


SMRT Leiden

Although we sure missed spending a few glorious spring days in the stunning Dutch city of Leiden, we were delighted to make our annual European user gathering international. This fave meet-up included not only top talks by plant, animal, human and microbial scientists, but also a strong offering of bioinformatics sessions. Keynotes included Vertebrate Genomes Project leaders Erich Jarvis (@erichjarvis) and Sergey Koren (@sergekoren) from the National Institute of Health.

Register here to watch these presentations on-demand.


Advances in Genome Biology and Technology (AGBT) Conference

One of the last conferences we were able to attend in person, AGBT featured several informative sessions. Tina Graves-Lindsay from the McDonnell Genome Institute (@GenomeInstitute) described how her team is using PacBio sequencing to produce reference-grade human genome assemblies. Adam Ameur (@_adameur) from Uppsala University discussed the use of long-read sequencing to detect off-target results from CRISPR-Cas9 gene editing studies. And Brenda Oppert from the USDA made a convincing argument for developing insect-based food sources for people.



PacBio Neuroscience Day

Our first all-day event dedicated to neuroscience, #PBNeuroDay showcased a lot of emerging rare disease research. From unravelling repeat expansions to creating new methods of carrier screening, the 25 sessions tackled a wide array of topics and diseases, from ALS, Alzheimers and Ataxia to Muscular Dystrophy, Parkinson’s, Progressive Supranuclear Palsy and Schizophrenia. 

Register here to watch these presentations on-demand


American Society of Human Genetics (ASHG) 

ASHG featured a wide variety of talks and video poster presentations covering a range of applications using PacBio long-read sequencing technology, from single-cell isoform analysis of the nervous system (by Hagen Tilgner @hagentilgner of Weill Cornell) to solving rare disease cases in children (by Emily Farrow of Children’s Mercy). After hearing from our users, be sure to check out the handy overviews by PacBio experts Aaron Wenger and Liz Tseng (@magdoll).



Introducción a la Secuenciación Larga y Precisa con PacBio 

This Spanish language webinar was a huge hit. Carmen Guarco, Senior Field Application Scientist specializing in bioinformatics, was joined by Álvaro G. Hernandez (@UIUC_DNAseq), Director of DNA services at the Roy J Carver Biotechnology Center at the University of Illinois at Urbana-Champaign to offer an overview of PacBio technology and tips for getting the most out of HiFi reads. 



Beyond a Single Reference Genome – The Advantages of Sequencing Multiple Individuals

As it becomes increasingly clear that single reference genomes for each species are not enough, many scientists are interested in creating pangenome collections. So we brought together two experts — Kevin Fengler of Corteva and Matthias H. Weissensteiner (@MWeissensteiner) of Penn State to discuss the advantages of sequencing multiple individuals to gain comprehensive views of genetic variation, and the speed, cost, and accuracy benefits of using HiFi reads to sequence species of interest.



A HiFi View: Sequencing the Gut Microbiome with Highly Accurate Long Reads

How can the Sequel II System help with complex metagenomics projects? Meredith Ashby (@AsbhyMere), Director of Microbial Genomics at PacBio, was joined by Bing Ma of the Institute of Genome Science at the University of Maryland, who discussed her work using long-read sequencing to identify high-resolution microbial biomarkers associated with leaky gut syndrome in premature infants. George Weinstock (@geowei) of The Jackson Laboratory, talked about the potential of highly accurate long reads enabling strain-level resolution of the human gut microbiome by resolving intraspecies variation in multiple copies of the 16S gene.



Long-Read Sequencing in COVID-19 Research

We’d be remiss not to mention our talks covering COVID-19 itself. In the Labroots webinar Opportunities for using PacBio Long-read Sequencing for COVID-19 Research, Meredith Ashby, Director of Microbial Genomics at PacBio, described how HiFi sequencing could be used for mutation phasing and rare variant detection to understand viral stability and mutation rates, as well as providing insights into viral population structure for monitoring viral evolution. In Understanding SARS-CoV-2 and Host Immune Response to COVID-19 with PacBio Sequencing, Melissa Laird-Smith (@SmithLab_UofL) discussed her work evaluating the impact of host immune restriction in health and disease with high resolution HLA typing and Corey Watson (@ctwatson29) of the University of Louisville School of Medicine talked about overcoming complexity to elucidate the role of IGH haplotype diversity in antibody-mediated immunity. 



We look forward to plenty more new discoveries in 2021 – Happy New Year!


Subscribe for blog updates:




Press Release

PacBio Grants Equity Incentive Award to New Employee

Friday, December 3, 2021