Staphylococcus aureus multilocus sequence type 398 (ST398) is responsible for an increasing number of severe infections in humans. There are no reports detailing if all ST398 strains are equally virulent. We present the genome sequence of the moderate-virulence ST398 methicillin-susceptible Staphylococcus aureus strain GD1108, determined in a Caenorhabditis elegans infection model, to reveal the ST398 sublineage virulence.Copyright © 2019 McClure et al.
The emerging livestock-associated Staphylococcus aureus multilocus sequence type 398 (ST398) appears to have augmented virulence in humans. However, it is unclear if all ST398 strains are equally virulent. Here, we present the chromosomal sequence of a low-virulence ST398 methicillin-susceptible S. aureus (MSSA) strain, GD1696, to investigate ST398 sublineage virulence.Copyright © 2019 McClure et al.
Multilocus sequence type 398 (ST398) methicillin-susceptible Staphylococcus aureus (MSSA) has been shown to have augmented pathogenicity in humans. However, it has not been determined whether all ST398 strains are equally virulent. We present here the genome sequence of a high-virulence ST398 MSSA strain, GD487, to explore potential insights into ST398 virulence.Copyright © 2019 McClure et al.
Predominant community-associated methicillin-resistant Staphylococcus aureus strain USA300 is believed to have originated from an ancestral methicillin-susceptible strain, although the details of that evolution remain unknown. To help understand the emergence of this highly successful strain, we sequenced the genomes of two methicillin-susceptible Staphylococcus aureus clinical strains that are very closely related to USA300. Copyright © 2019 McClure and Zhang.