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Tuesday, October 27, 2020

ASHG PacBio Workshop: Latest product and application updates

In this ASHG 2020 PacBio Workshop Jonas Korlach, CSO, shares how the new PacBio Sequel IIe System makes highly accurate long-read sequencing easy and affordable so?all scientists can gain comprehensive views of human genomes and transcriptomes. He goes on to provide updates on the applications including human WGS for variant detection, de novo genome assembly, single-cell full-length RNA sequencing, and targeted sequencing using PCR and No-Amp methods.

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Tuesday, October 27, 2020

ASHG CoLab: PacBio HiFi reads for comprehensive characterization of genomes and single-cell isoform expression

In this ASHG 2020 CoLab presentation hear Principal Scientists, Aaron Wenger and Elizabeth Tseng share how highly accurate long reads (HiFi reads) provide comprehensive variant detection for both genomes and transcriptomes. Aaron Wenger describes how new improvements in protocols and analysis methods have increased scalability and accuracy of variant calling. As demonstrated in the precisionFDA Truth Challenge V2, HiFi reads (>99% accurate, 15 kb – 20 kb) now outperform short reads for single nucleotide and structural variant calling and match for small indels. This includes calling >30,000 small variants and >10,000 structural variants missed by short reads, many in medically…

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Sunday, October 25, 2020

Video Poster: Capture long-read isoform sequencing (Iso-Seq) for uncovering human isoform diversity in the brain and characterizing SARS-CoV2 viral RNAs

Most genes in eukaryotic organisms produce alternative isoforms, broadening the diversity of proteins and non-coding RNAs encoded by the genome. In contrast to other RNA sequencing platforms that rely on short-read sequencing, long accurate reads from PacBio Single Molecule, Real-Time (SMRT) Sequencing can characterize full-length transcripts without the need for assembly and inference. The PacBio isoform sequencing (Iso-Seq) method generates full-length sequences for transcripts up to 10 kb in length, with scalable throughput using barcoding approaches. The Iso-Seq application can be employed for a wide variety of studies, including improvement of gene annotation, identification of novel isoforms and fusion transcripts,…

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Sunday, October 25, 2020

PAG PacBio Workshop: A fungal transcriptome uses complex and double-edged isoforms to split wood

From USDA’s Agricultural Research Service, molecular biologist Sean Gordon discusses the need for long-read sequencing to map an organism’s transcriptome. His team analyzed the wood-decaying fungus Plicaturopsis crispa first with short reads and found that they were missing exons and other important information. They switched to SMRT Sequencing so they could observe, rather than infer, full-length transcripts.

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Sunday, October 25, 2020

Seminar: No assembly required – extremely long reads for full-length transcript isoform sequencing

PacBio CSO Jonas Korlach describes the Iso-Seq method for full-length transcript isoform characterization using SMRT Sequencing. He presents published research using the method for full isoform characterization, including papers from Stanford scientists who analyzed full transcriptomes with SMRT Sequencing. With the Iso-Seq method, researchers found novel isoforms and novel genes even in well-studied cell lines.

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Sunday, October 25, 2020

Webinar: Gain new insights in genome and transcriptome research with >10,000 bp reads

Jonas Korlach, CSO of PacBio, discusses the scientific value of >10 kb, unbiased sequencing reads for an expanding range of applications. Single molecule, real-time (SMRT) Sequencing technology has rapidly advanced in read lengths, throughput and adoption in the past year – a review of published work from a variety of researchers utilizing these new capabilities is also conducted.

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Sunday, October 25, 2020

Labroots Webinar: More comprehensive views of human genetic variation

In this BioConference Live webinar, PacBio CSO Jonas Korlach highlights how multi-kilobase reads from SMRT Sequencing can resolve many of the previously considered ‘difficult-to-sequence’ genomic regions. The long reads also allow phasing of the sequence information along the maternal and paternal alleles, demonstrated by full-length, fully phased HLA class I & II gene sequencing. In addition, characterizing the complex landscape of alternative gene products is currently very difficult with short-read sequencing technologies, and he describes how long-read, full-length mRNA sequencing can be used to describe the diversity of transcript isoforms, with no assembly required. Lastly, in the exciting area of…

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Sunday, October 25, 2020

ASMS Conference: Approaching the ‘perfect’ database – single-molecule, full-length transcript sequencing to create sample-specific, full-length protein databases

Recent advances in DNA sequencing technologies based on single-molecule detection now enable determination of full-length transcript sequences and, thus, all protein sequences in a sample. Utilizing data from this exciting technology, we have constructed customized, full-length protein databases that offer unprecedented advantages in proteomics database searching. Protein inference from bottom-up proteomics data can now be conducted using the set of correct protein sequences actually expressed in the sample, meaning that peptide identifications can be understood in the context of their corresponding full-length protein sequences. And most importantly, novel peptides or proteins originating from variations in the genome or transcriptome can…

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