Menu
March 3, 2015  |  

PacBio at AGBT

Pacific Biosciences held a star-studded workshop to show off the feats that can be accomplished with its SMRT (Single Molecule, Real-Time) sequencers, the instruments of choice for recovering long-range structural information on the genome.


March 1, 2015  |  

When Whole Genome Sequencing Doesn’t Give Us the Whole Genome

As its throughput and average read length have continued to increase, customers have been using the technology for larger and larger genomes. Now, a number of customers are using the technology to de novo sequence whole human genomes, according to presentations at last week’s AGBT meeting.


February 1, 2015  |  

Decoding the Unsequenceable

In case you’re not aware, the human genome is not completely sequenced. Regions of repeats and hard to decode sequence continue to elude scientists. And then there is the challenge of genetic variation. Nathan Blow looks at new technologies and methods that could help map these and other difficult-to-read stretches of DNA.


November 18, 2014  |  

‘Platinum’ Genome Takes on Disease

Geneticists have a dirty little secret. More than a decade after the official completion of the Human Genome Project, and despite the publication of multiple updates, the sequence still has hundreds of gaps – many in regions linked to disease. Now, several research efforts are closing in on a truly complete human genome sequence, called the platinum genome.


November 12, 2014  |  

Next-Gen DNA Sequencing: Fall 2014 Update

Sequencing instrumentation hasn’t changed since we last looked at the market in February 2014, but that’s not to say all is as it was. New sample-preparation instruments have arrived on the scene, in addition to new, ever-longer sequencing chemistries.


October 15, 2014  |  

The New World of Isoform Sequencing

Scientists have begun applying long-read sequencing to further advance the field of gene expression, finding that this method can directly sequence full-length transcripts and provide additional insights into gene isoforms.


October 10, 2014  |  

Blend Long and Short Reads for Better mRNA Isoform Analysis

To mangle the old saw, there’s more than one way to sequence a transcriptome. For some researchers, the goal is counting transcripts to assess expression levels‰ÛÓa sequencing-based alternative to DNA microarrays. Others are interested in transcript architecture. Eukaryotic genes are often alternatively spliced, and the choice to include or exclude particular exons can have profound biological consequences.


Talk with an expert

If you have a question, need to check the status of an order, or are interested in purchasing an instrument, we're here to help.