April 23, 2021
Asset Tag: RNA sequencing
February 5, 2021
ASMS Conference: Approaching the ‘perfect’ database – single-molecule, full-length transcript sequencing to create sample-specific, full-length protein databases
Recent advances in DNA sequencing technologies based on single-molecule detection now enable determination of full-length transcript sequences and, thus, all protein sequences in a sample. Utilizing data from this exciting…
February 5, 2021
Labroots Webinar: More comprehensive views of human genetic variation
In this BioConference Live webinar, PacBio CSO Jonas Korlach highlights how multi-kilobase reads from SMRT Sequencing can resolve many of the previously considered ‘difficult-to-sequence’ genomic regions. The long reads also…
February 5, 2021
Podcast: The progress of clinical genomics in Sweden
Ulf Gyllensten speaks about advances in screening for HPV, his predictions for the widespread use of genome sequencing in the clinic, and applications using Single Molecule, Real-Time (SMRT) Sequencing for…
February 5, 2021
Podcast: Short read sequencing not up to the task of characterizing transcriptome says Mike Snyder of Stanford
Mike Snyder from Stanford University has published recent papers in Nature Biotechnology and PNAS using SMRT Sequencing for transcriptome analysis and demonstrated that long reads enable full coverage of RNA molecules. He discusses that…
February 5, 2021
PAG 2016 Highlights: Customer interviews
See what PacBio users had to say about SMRT Sequencing at the Plant and Animal Genome (PAG) Conference in San Diego. This brief video captures highlights from posters, presentations, and…
February 5, 2021
PAG PacBio Workshop: Using the Iso-Seq method to fill in your a_no__tion
Richard Kuo from the Roslin Institute gave this PAG 2017 talk about using the PacBio Iso-Seq data to generate genome annotations that outperform current gold-standard annotations. Included: findings from a…
February 5, 2021
ASHG Virtual Poster: Alternative splicing in FMR1 premutations carriers
In this ASHG 2016 virtual poster, Flora Tassone from UC Davis describes her study of the molecular mechanisms linked to fragile X syndrome and associated disorders, such as FXTAS. She…
February 5, 2021
AGBT PacBio Workshop: SMRT Sequencing roadmap: better throughput, lower costs
In this AGBT 2017 talk, PacBio CSO Jonas Korlach provided a technology roadmap for the Sequel System, including plans the continue performance and throughput increases through early 2019. Per SMRT…
February 5, 2021
AGBT Virtual Poster: Using the PacBio Iso-Seq method to search for novel colorectal cancer biomarkers
Early detection of colorectal cancer (CRC) and its precursor lesions (adenomas) is crucial to reduce mortality rates. The fecal immunochemical test (FIT) is a non-invasive CRC screening test that detects…
February 5, 2021
AGBT Virtual Poster: Interspecies interation amoung meat spoilage-related lactic acid bacteria
In this AGBT 2017 poster, the University of Helsinki’s Petri Auevinen reports on efforts to understand bacteria that grow on, and subsequently spoil, food. This analysis monitored DNA modifications and…
February 5, 2021
AGBT Virtual Poster: Quantifying the impact of improved genome assemblies on functional genomics
In a poster presented at AGBT 2017, Fritz Sedlazeck from Johns Hopkins University describes the comparison of genome assemblies produced using long-read PacBio sequencing and short-read sequencing with 10x Genomics…
February 5, 2021
Webinar: A new paradigm in DNA sequencing – Highly accurate single-molecule long reads
In this webinar, Jonas Korlach, PacBio Chief Scientific Officer, and Dave Corney, Associate Principal Scientist, Next Generation Sequencing from GENEWIZ, describe the recent release of Sequel System 6.0, which has…
February 5, 2021
PAG Conference: Iso-Seq analysis for plant & animal genomes – annotation evaluation & phasing
In this presentation, Elizabeth Tseng explains how PacBio’s full-length RNA Sequencing using the Iso-Seq method can characterize full-length transcripts without the need for computational transcript assembly. The Iso-Seq method is…
February 5, 2021
PAG Conference: How SMRT Sequencing is accelerating plant and animal genomics
In this presentation, Justin Blethrow provides an overview of recent and upcoming developments across PacBio’s SMRT Sequencing product portfolio, and their implications for PacBio’s major applications. In presenting the product…