The coffee’s cold, your pipette tips are backordered, and someone just booked your favorite lab bench. Science can be full of small annoyances. We can’t solve them all, but we can tackle one of the biggest ones: when inaccurate or incomplete sequencing data leaves you with more questions than answers.
That’s why we just kicked off There’s HiFi for that — a new wave of practical resources, short videos, and behind-the-scenes stories to get you oriented, inspired, and equipped with tools that make long-read sequencing in your lab feel refreshingly possible. Whatever genome you’re dealing with, HiFi sequencing helps you move from ambiguity to clarity, with results you can actually trust.
Along the way you’ll get access to the HiFi starter pack, a toolkit including a Sequencing 101 guide, a grant cheat sheet to get a head start on funding, and access to a curated playlist of short, insightful videos designed for real lab life.
You’ll also be eligible for a chance for us to pick up the tab to the genomics conference of your choice — registration, travel, and hotel* — because sometimes the best way to see what’s possible is to see it up close.
Feel like your sequencing data isn’t telling the whole story?
You’re not alone. Many genomic researchers face the same frustrations: data that feels incomplete, results that aren’t reliable, and tools that fall short when it matters most.
If you’re still relying on short-read or other long-read platforms, you may be all too familiar with this unsettling feeling. Read on to learn how HiFi sequencing helps you move past these challenges with clarity and confidence.
When you feel like something’s missing
Sticking with what’s familiar might feel safe, but if you’ve ever questioned your results, you’re not alone. Short reads can miss key regions and leave gaps that hide critical insights.
HiFi gives you the full picture.
Our long, highly accurate reads span entire regions so you don’t have to guess or piece things together. You’ll see more, with more confidence.
And what can you do with a single, accurate, long read? Quite a lot. HiFi sequencing lets you interrogate major variant types (SNVs, indels, structural variants, repeat expansions) in a single workflow. HiFi reads are long enough to span tricky regions and phase variants, and accurate enough to call them with confidence.
That means your sample works harder for you. Instead of toggling between tools and technologies, you can capture a complete picture from the start. Structural variants no longer hide in plain sight, and tandem repeats become clear. You stop second-guessing your data and start making decisions that move the science forward.
HiFi also gives you access to native methylation information directly from the same sample, with no bisulfite conversion or special prep needed. Both 5mC and 6mA methylation are detected simultaneously in each run, you can now employ the Fiber-seq method and explore chromatin accessibility too. This brings a more complete dimension to the epigenome, all with the same workflow.
Short reads can tell you which genes are being expressed, but not exactly which isoforms are doing the work. HiFi sequencing delivers full-length transcripts with base-level accuracy, revealing the true structure of gene expression, whether across bulk samples, within single cells, or for 16S rRNA sequencing.
When you’re spending too much time (and money) re-doing analyses
You know the feeling: When your data comes back murky, you run multiple tests, re-analyze, or re-sequence your samples just to get clear answers. Those costs all add up fast.
HiFi helps you get it right the first time. With better coverage and accuracy, you can reduce repeat experiments and stop burning resources just to clean up unclear results.
HiFi reads consistently deliver 99.9% accuracy while spanning long genomic and transcriptomic regions. That combination eliminates the traditional tradeoff between length and confidence. You get cleaner variant calls, more complete assemblies, and better isoform detection, without resorting to secondary validation or stitching.
That clarity shows up in the places that matter most:
- Tandem repeats implicated in neurological disorders
- GC-rich regions that skew coverage or mislead variant callers
- Fusion transcripts, splice variants, and other RNA changes in cancer
- Complex gene families like HLA and pharmacogenes
It also shows up in the workflow itself. More uniform coverage means less wasted time chasing down gaps. Fewer inaccurate variant calls means less downstream cleanup. And with native methylation and chromatin accessibility, your data does double duty from the first run.
HiFi doesn’t just make sequencing better. It makes it more conclusive.
HiFi sequencing to fit your question, not just your protocol
Every lab has a unique mix of questions, constraints, and goals. What makes HiFi stand out is how easily it adapts to meet them. From rare disease to metagenomics, gene expression to genome assemblies, there’s a clear path forward.
What problem are you solving next?
There’s HiFi for that isn’t just a catchphrase, it’s a reflection of something much bigger: the idea that long-read sequencing can be accessible, adaptable, and accurate enough to answer nearly every type of genomics question. From everyday research hurdles to long-standing biological mysteries, HiFi sequencing gives you the resolution and reliability to move forward confidently. Whether you’re new to long reads or already pushing their limits, this initiative meets you where you are.
Get resources worth bookmarking. Watch videos worth sharing. And maybe even take your research on the road to a genomics conference that redefines what’s possible in your research.
But more than that, start asking bolder questions and start getting clearer answers. And stop wondering if the tool you’re using is leaving something out.
Because whatever your lab is up against…
*Terms and conditions apply.