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掌握全局

通过全面监控、完整的基因组信息以及准确追踪,可更好地实现保护全球健康。自从在技术上首次实现病原微生物的常规测序以来,如今这方面已取得了巨大的进展。

构建一份更全面的微生物病原体的基因组视图

单分子实时(SMRT)测序的出现大大提高了人们对微生物基因组学、致病性和耐药性的认识。PacBio系统可带来迄今为止最全面的遗传信息。有了SMRT测序,政府机构、医疗保健中心及其它公共卫生机构就能够:

  • 获得完整的基因组组装,更加深入地了解社区获得性和医院相关的感染和传播
  • 利用微生物表观遗传学来进一步表征全球爆发、世界大流行和地区流行
  • 快速解析病毒群体,让当地和全球各方准备和应对季节性和年度性感染
  • 表征复杂群落,以支持食源性病原体的监控和追踪

研究聚焦:长序列阐明抗生素耐药性的遗传学机理

科学家研究耐药细菌的移动基因组,以了解它们的适应能力。这项研究表明,复制型转座子和同源重组是抗性质粒重排和进化的驱动力。深入了解这项研究:

He, S. et al., 2016. Mechanisms of evolution in high-consequence drug resistance plasmids. mBio, 7(6), pp.e01987–16.

研究聚焦:在序列的人类隔离群中的探索真菌耐药性

长读长测序让科学家能够从HIV阳性患者中分离出的光滑念珠菌(Candida glabrate)中发现100个粘附素样基因。对粘附素生物学特性的更广泛了解将有助于对抗这种真菌病原体的增强毒力。 深入了解这项研究。

Vale-Silva, L.A. et al., 2017. Comparative genomics of two sequential Candida glabrata clinical isolates. bioRxiv, Preprint.

若有意了解SMRT测序如何推动您的公共卫生研究,请联系我们

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