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The Award-Winning Sequel II System

Delivering Highly Accurate Long Reads

The Sequel II System provides the advantages of SMRT Sequencing and now makes it more affordable for all scientists to drive discovery with comprehensive views of genomes and transcriptomes.

  • Produces the exceptional results customers have come to expect from PacBio Systems
  • Generates ~8-times more data than the original Sequel System
  • Provides access to even more highly accurate long reads (HiFi reads) – Learn more about HiFi reads
  • Reduces project time for faster results
  • Makes sequencing more affordable
  • Supports the range of SMRT Sequencing applications

Setting a New Standard in Long-Read Sequencing

The Sequel II System has been recognized for its ability to generate longer reads with greater accuracy and throughput, at a significantly lower cost.
Learn More

Sequel II System 2.0 Release

The Sequel II System 2.0 release features major improvements to system performance through our 2.0 consumables, SMRT Cell 8M, Sequel ICS v8.0, and SMRT Link v8.0. Combined, these enhancements make SMRT Sequencing more efficient and affordable.

With this release we have improved average read lengths up to 50% which allows you to generate more HiFi data per SMRT Cell 8M and enables:

    • Sequencing of larger inserts (15-20 kb) to support de novo assembly applications with HiFi data
    • High precision and recall for variant detection with fewer SMRT Cells per sample by using ~15 kb HiFi reads
    • Characterization of a whole transcriptome in a single SMRT Cell 8M and increased detection of long isoforms
    • Multiplexing two samples per SMRT Cell 8M for structural variant detection
    • Multiplexing up to 48 microbial samples per SMRT Cell 8M for de novo assembly

What Can You Do with a Single SMRT Cell 8M?

 

Discover what’s now possible with a single SMRT Cell 8M, and learn about pricing for our SMRT Sequencing Applications.

Learn More

See the 2.0 Chemistry Release Performance

Explore these Sequel II System Datasets

Ready to Get Started with the Sequel II System?

 



Previous Release Information

Sequel System 6.0 Release