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Sequel IIe System - Sequencing evolved

Based on the Proven Performance of the Award-Winning Sequel II System, the Sequel IIe System Delivers:

  • Direct access to the only highly accurate long reads: PacBio HiFi reads
  • Deeper biological insights, less data processing, and faster results thanks to the unmatched clarity of HiFi reads
  • Reliable and affordable high-throughput sequencing for a broad range of applications

Key Benefits of HiFi Sequencing on the Sequel IIe System:

  • Better data for superior results with lower coverage, from a single technology
  • Less time spent on data processing and analysis for faster answers
  • Cost savings at every step of your sequencing pipeline

 


New: HiFi Sequencing and Software v10.1 Release

PacBio is thrilled to share our latest release which increases workflow scalability, improves usability, and reduces DNA input requirements for HiFi whole genome sequencing applications.

The workflow improvements, developed in partnership with Children’s Mercy Kansas City, further empower our customers to sequence hundreds to thousands of genomes per year on the Sequel II or IIe Systems.

Discover what’s new:

 

Library Prep

The updated HiFi SMRTbell library template preparation Procedure & Checklist offers significantly reduced DNA input requirements, 5 μg DNA input down from 15 μg, enabling HiFi whole genome sequencing with limited sample quantities (blood, tissue biopsies).

Access PacBio Documentation

The workflow is now more efficient, scalable, and automation-friendly for parallel library construction of 16 samples with manual prep, or 96 samples using this automation-friendly workflow to facilitate increased throughput in labs with multiple instruments.

New Consumables include: Sequel II Binding Kit 2.2, SMRTbell Enzyme Clean-up Kit 2.0, and Sequencing Primer v5, as well as Consumable Bundles

Explore these New Consumables and Contact Sales for Pricing


HiFi Sequencing

The improvements to the workflow increase the number of HiFi reads at or above 99.9% accuracy (QV30) for HiFi whole genome sequencing-based applications on the Sequel II and IIe Systems and improve the quality of genome assemblies.

With industry-leading reliability and performance, the Sequel II and IIe Systems now support high-volume sequencing of hundreds to thousands of genomes per year.

Learn more about our Whole Genome Sequencing Applications or Explore Example Datasets


Data Analysis

SMRT Link v10.1 and Instrument Control Software (ICS) v10.1 are now available for all Sequel II and IIe System users. Key features include improved application-centric Sample Setup and Run Design, the incorporation of our new HiFiViral for SARS-CoV-2 analysis application, and updates to the Iso-Seq Analysis application for multiplexed samples.

Additionally, this release brings the SMRT Link v10.0 features, including optional full workflow cloud integration, and our latest Genome Assembly application, to all Sequel System customers.

Download SMRT Link v10.1


 

New Workflow: Scalable Human Whole Genome HiFi Sequencing for Rare and Inherited Disease Research

This release provides an efficient and scalable workflow, developed in collaboration with Children’s Mercy Kansas City, for high-throughput sequencing and comprehensive variant detection research to better understand the genetic causes of rare and inherited diseases. Learn more about Rare Disease Research.

 

 

 

 

 


Want to Trade Up to HiFi Sequencing on the Sequel IIe System?

With this limited-time offer you can Trade In your Oxford Nanopore PromethION, GridION, or select Illumina or ABI sequencing systems for credit towards a new Sequel IIe System.

 

 

*Restrictions apply, see promotion details for more information.

Complete the form below to inquire about Trading Up.


 

Ready to Get Started with the Sequel IIe System?

Contact us to request pricing or have questions answered about the Sequel IIe System


See Previous System Releases