Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Data Release: Human Microbiome Samples Demonstrate Advances in HiFi-Enabled Metagenomic Sequencing
As technology developers, one of our greatest joys is seeing how customers take our sequencing tools and deploy them for innovative and compelling new projects. Metagenomics has been one of…
Announcing the Winners of Our Clinical Research SMRT Grant – Two Scientists at the Forefront of Discovery
Here at PacBio, we have had the privilege of awarding many SMRT Grants to intrepid scientists who believe that HiFi sequencing data can help them achieve their goals. Recently, we…
For Metagenomic Studies, HiFi Reads Deliver Higher-Quality Data
A new paper from scientists at the Max Planck Institute offers a great look at how HiFi sequencing delivers significantly improved results for metagenome studies compared to short-read data. In…
Iso-Seq Analysis Provides Insights into Feats of Physiology of Hibernating Bears
Hibernating bears have heart rates of 10-15 beats per minute, yet they do not develop congestive heart failure. Despite accumulating enormous amounts of fat and acquiring insulin resistance, they do…
Iso-Seq Analysis Enthusiasts Share Research Wins at Virtual Social Event
Been itching to talk about your latest single-cell experiments, your favorite differentially expressed isoforms, or your latest and greatest software for visualizing alternative splicing, but thwarted by a worldwide pandemic…
In Case You Missed It — Sequel IIe System Users Share Their First Time Experiences
The new kid on the PacBio block — The Sequel IIe System — has been receiving high marks from universities and sequencing centers around the world. What’s it like using…
Minding the Gaps: International Team Creates First Two Gapless Rice Reference Genomes
Rice was the first crop genome ever completed almost two decades ago. However, the rice reference has never been truly complete. Even improved versions of the major food staple and…
Sequencing 101: How does whole genome sequencing help us understand rare diseases?
Updated on March 2, 2023 Rare diseases are defined as diseases that affect a small number of people — fewer than 1 in 2,000 in the European Union and…
NIH Scientists Chart SARS-CoV-2 Evolution Within an Individual Over Time
An exciting new paper from scientists at the National Institute of Allergy and Infectious Diseases and the NIH Clinical Center reports on the evolution of the SARS-CoV-2 virus within individuals….
Reaching a genomics milestone — the first complete human genome
It’s a moment three decades in the making: the first complete human genome assembly is here! Reading this you will no doubt feel some sense of déjà vu. After all,…
Scientists Use PacBio Sequencing to Discover Likely Pathogenic Structural Variants Linked to ALS
May is ALS Awareness Month, and we’re hoping to help raise awareness by shining a spotlight on two deserving publications from scientists at the University of Washington and at the…
Sequencing 101: DNA extraction — tips, kits, and protocols
If you are like most of us at PacBio, you likely learned how to extract DNA in a high school or college biology class, or maybe even in your…
Pandemic Preparedness: PacBio and Labcorp Team Up On a Global Pan-Pathogen Surveillance Network
If only we could track COVID-19 like we track the weather, with satellites and weather stations placed around the globe monitoring and sounding the alarm about potential storms, floods, droughts…
New HiFi Sequencing Workflow and Software Update Streamlines Whole Genome Sequencing
Today we’re pleased to announce the launch of a new HiFi Sequencing workflow along with a software update for the Sequel II and Sequel IIe Systems that will increase the number of…
Conservation is For Life, Not Just For Earth Day
By Jonas Korlach, Chief Scientific Officer Grapy dusks over tangerine fields. Potato-patch fog over beds of coral. Mountains, glaciers, forests, deserts, fertile farmland and seas with both Arctic…