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Resolve Complex Human Genetic Variation with Confidence

Apply to win free sequencing to drive new discoveries in your clinical research with PacBio highly accurate long reads–HiFi reads.

How Will HiFi Reads Help You Understand Human Health and Disease?

  • Get Sanger-quality accuracy (>99.9%) and long read lengths (up to 25 kb) using a single technology solution
  • Comprehensively detect and phase all variant types, from SNVs to structural variants, including 5% more variants in the medical exome
  • Use the uniform coverage of HiFi reads to sequence through hard-to-access regions of the human genome including repeat expansions, promoters and flanking regions of transposable elements

HiFi Reads Can be Used Across a Range of Applications for Clinical Research

Targeted Sequencing for accurate detection of all variant types in specific genes or regions using either an amplicon or amplification-free approaches
Variant Detection for comprehensive detection of all variants in the genome with high precision and recall
Whole Genome Sequencing for generation of reference-quality de novo genome assemblies
 

RNA Sequencing to gain a complete view of transcript isoform diversity – no assembly required – for bulk or single-cell approaches


 

Need Inspiration? Learn how our 2019 SMRT Grant winner, Stéphanie Tomé, used SMRT sequencing to detect clinically significant repeat changes in triplet expansion disorders. Read the blog post.

 


 

The Clinical Research SMRT Grant Program is Open – Apply Now

How to Apply for the SMRT Grant

Tell us how HiFi sequencing will help you advance your clinical research for a chance to win:

  • Construction of up to 6 SMRTbell libraries
  • Sequencing of up to 6 SMRT Cells 8M on the Sequel II System
  • Bioinformatics support

What Can You Do with Six SMRT Cells?

Things to know about this SMRT Grant Program:

  • We encourage scientists of all career stages to apply!
  • You can read the official rules and reach out if you have questions about this SMRT Grant.
  • One winner will be selected from all qualified applications by a panel of scientists from PacBio and Icahn Institute for Data Science and Genomic Technology.
  • The submission window closes: Friday, June 11, 2021 at 5:00 p.m. PDT

Learn about our Co-Sponor

 


The Icahn Institute for Data Science and Genomic Technology at Mount Sinai is dedicated to developing new technologies that foster discovery and advance clinical practice. Our scientists are experts in a wide array of genomics and sequencing technologies spanning both bulk and single-cell sequencing methods. We are also at the forefront of method development, allowing us to offer cutting edge protocols including extremely low-input library preparation and PCR-free enrichment strategies for targeted sequencing of both DNA and RNA.

Submit Your Proposal

Note: If submitting multiple proposals, please ensure you use a unique email address for each submission.

Don’t want to wait to get started with HiFi sequencing? Connect with a PacBio scientist today.