Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Webinar: Using SMRT Sequencing to Understand SARS-CoV-2 and the Host Immune Response
As the flurry of research around the SARS-CoV-2 virus continues at an unprecedented pace, scientists are beginning to tackle some of the more complex immunological responses with the help of…
Sequencing 101: understanding accuracy in DNA sequencing
For scientists who utilize DNA sequencing in their research but are not experts in the underlying technology, it can be difficult to determine the accuracy of sequencing results — and…
The Pathologist: Solving Rare Disease with SMRT Sequencing
The strides scientists have made in rare disease research lately is truly impressive. For an overview of recent progress, we encourage you to check out a new article in The…
Data Release: HiFi Sequencing Results for Plants, Animals, and Microbes
UPDATE — November 17, 2020: This paper is now published in Scientific Data. ORIGINAL POST It’s been more than a year since we introduced HiFi sequencing to generate highly accurate…
Sequencing 101: looking beyond the single reference genome to a pangenome for every species
What is a pangenome? Unless you have an identical twin, no other person has a genome that is identical to yours. The same is true for other animal, plant, and…
Delivering New Insights into Cancer Research: SMRT Sequencing Case Studies
Will the next big cancer breakthrough be in immunotherapy? Therapeutic modification of the tumor microenvironment or microbiome? Or early detection and screening? Whatever the result, long-read sequencing technology can play…
Sequencing 101: why are long reads important for studying viral genomes?
The COVID-19 pandemic has brought a sudden urgency to virus research and led many of us to dig more deeply into all the tools available for characterizing viral genomes, from…
Go Big or Go Home — Tackling a Giant Genome
California redwoods: Not only are they giants in height and age (up to 379 feet high, 29 feet round, and thousands of years old), but the famous towering trees are…
How Long-read Sequencing Can Help Researchers Address Pressing Questions in COVID-19 Pandemic
Herculean efforts are being made by scientists around the world to respond quickly to the COVID-19 crisis in a race to understand the virus causing the pandemic and develop diagnostics,…
In Battle Against COVID-19 Pandemic, Scientists Turn to PacBio Sequencing
Our team is proud to announce that PacBio has been working closely with customers to help in the fight against the COVID-19 pandemic. Scientists in commercial, academic, and government research…
Sequencing 101: video introduction to PacBio sequencing and the Sequel II system
We’re pleased to release a short video describing PacBio sequencing and our latest platform, the Sequel II system. If you’ve ever wondered how Single Molecule, Real-Time (SMRT) sequencing works, what…
HiCanu for HiFi Reads Produces First Assembly of Human Segmental Duplications and Centromeres
UPDATE — September 1, 2020: This paper is now published in Genome Research. ORIGINAL POST — April 1, 2020 In a new preprint, scientists from the National Human Genome Research…
AGBT 2020 Highlights: Reference-Grade Assemblies, Iso-Seq Data, and More
It was a pleasure to attend the annual Advances in Genome Biology & Technology meeting in sunny Marco Island, Fla., last month. The conference has a long history of supporting…
Prokaryotic Methylation Detection on the Sequel II System
Since the first PacBio instrument was released in 2011, methylation detection has been one of the advantages of SMRT Sequencing. The kinetics of nucleotide incorporation change as the DNA polymerase…
A Menagerie of New Genomes Released by International Ensembl Project
Meerkats, yaks, geese, and lots of flies — oh my! A full menagerie of new and updated animal genomes has been released by the Ensembl project. The Ensembl 99…