September 22, 2019  |  

Complete nucleotide sequences of two KPC-2-encoding plasmids from the same Citrobacter freundii isolate.

Authors: Zheng, Beiwen and Huang, Chen and Xu, Hao and Yu, Xiao and Zhang, Jing and Wang, Xin and Jiang, Xiawei and Xiao, Yonghong and Li, Lanjuan

Large amounts of antibiotics are released from humans and animals into aquatic environments and lead to an increased abundance of environmental MDR bacteria, which pose a potential threat to public health. It is worrisome that the entry of carbapenemase-producing Enterobacteriaceae (CPE) into the environment is increasingly reported; these carbapenem-resistant bacteria pose a severe health threat as few therapeutic options are available for such pathogens. Although culture-independent approaches are capable of revealing the vast genetic diversity of the environmental resistome, there are few data regarding deeper characterization of mechanisms of environmental CPE isolates. Here, we describe the complete sequences of two blaKPC-2-containing plasmids present in the same Citrobacter freundii isolated from river sediment.

Journal: The Journal of antimicrobial chemotherapy
DOI: 10.1093/jac/dkx381
Year: 2018

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