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お問い合わせ

グローバルヘルスを改善する最先端のゲノム研究

病原体、移動因子、そして生物集団を特徴づけることが、より良いワクチン、治療と成果をもたらします。

深みのあるゲノムプロファイリングで研究を加速

PacBioの1分子リアルタイム(SMRT)シークエンスによる包括的なゲノム情報は、微生物ゲノム、病菌性および抗菌性耐性における理解を飛躍的に向上しました。PacBioシステムでは、下記の感染症研究が可能です。

スポットライト:SMRT シークエンスで病原体の複雑なゲノムを解明

ATバイアスで知られるPlasmodium falciparumゲノムにおける研究を実施。De novoアセンブリでゲノム構造と複雑性に新たな知見をもたらし、病原性、薬剤耐性、疾患感染の理解におけるリファレンスを報告しました。

Vembar, S.S. et al., 2016. Complete telomere-to-telomere de novo assembly of the Plasmodium falciparum genome through long-read (>11 kb), single molecule, real-time sequencing. DNA Research, 23(4), pp.339–351.

スポットライト:1分子シークエンスでHIV-1変異をトラッキング

新しいCircular Consensusアルゴリズムで、臨床検体におけるK103N薬剤耐性のウィルス進化をトラッキング。

Laird Smith, M. et al., 2016. An improved circular consensus algorithm with an application to detect HIV-1 Drug Resistance Associated Mutations (DRAMs). In 2016 ASM Microbe. New Orleans, LA.

SMRTシークエンスでグローバルヘルスを向上する最先端ゲノム研究を行うには、 ぜひお問い合わせください。

Selected Resources