July 7, 2019  |  

The complete genome sequence of the nicotine-degrading bacterium Shinella sp. HZN7.

Authors: Qiu, Jiguo and Yang, Youjian and Zhang, Junjie and Wang, Haixia and Ma, Yun and He, Jian and Lu, Zhenmei

Nicotine is a natural alkaloid that is very toxic to humans. To eliminate the harmful effects of nicotine in the environment, biological methods employing microbes to degrade nicotine are required (Brandsch, 2006; Liu et al., 2015). Shinella sp. HZN7 can degrade nicotine efficiently via the variant of a pyridine and pyrrolidine pathways (VPP; Ma et al., 2013; Qiu et al., 2014, 2015). The main intermediates in this pathway include 6-hydroxy-nicotine, 6-hydroxy-N-methylmyosmine, 6-hydroxypseudooxynicotine, 6-hydroxy-3-succinoyl-pyridine, and 2,5-dihydroxypyridine. This strain is the first nicotine-degrading bacterium to be isolated from the genus Shinella.

Journal: Frontiers in microbiology
DOI: 10.3389/fmicb.2016.01348
Year: 2016

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