July 7, 2019  |  

Pseudomonas aeruginosa clinical isolates in Nepal coproducing metallo-ß-lactamases and 16S rRNA methyltransferases.

Authors: Tada, Tatsuya and Shimada, Kayo and Satou, Kazuhito and Hirano, Takashi and Pokhrel, Bharat M and Sherchand, Jeevan B and Kirikae, Teruo

A total of 11 multidrug-resistant Pseudomonas aeruginosa clinical isolates were obtained in Nepal. Four of these isolates harbored genes encoding one or more carbapenemases (DIM-1, NDM-1, and/or VIM-2), and five harbored genes encoding a 16S rRNA methyltransferase (RmtB4 or RmtF2). A novel RmtF variant, RmtF2, had a substitution (K65E) compared with the same gene in RmtF. To our knowledge, this is the first report describing carbapenemase- and 16S rRNA methyltransferase-coproducing P. aeruginosa clinical isolates in Nepal. Copyright © 2017 American Society for Microbiology.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.00694-17
Year: 2017

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