July 19, 2019  |  

Initial assessment of the molecular epidemiology of blaNDM-1 in Colombia.

Authors: Rojas, Laura J and Wright, Meredith S and De La Cadena, Elsa and Motoa, Gabriel and Hujer, Kristine M and Villegas, Maria V and Adams, Mark D and Bonomo, Robert A

We report complete genome sequences of fourblaNDM-1-harboring Gram-negative multidrug resistant (MDR) isolates from Colombia. TheblaNDM-1genes were located 193Kb-Inc FIA, 178Kb-Inc A/C2 and 47Kb (unknown Inc type) plasmids. MLST revealed that isolates belong to ST10 (Escherichia coli), ST392 (Klebsiella pneumoniae), and ST322 and ST464 (Acinetobacter baumanniiandA. nosocomialis, respectively). Our analysis identified that the Inc A/C2 plasmid inE. colicontained a novel complex transposon (Tn125and Tn5393with 3 copies ofblaNDM-1) and a recombination "hotspot" for the acquisition of new resistance determinants. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.03072-15
Year: 2016

Read Publication

Talk with an expert

If you have a question, need to check the status of an order, or are interested in purchasing an instrument, we're here to help.