Retrospective analysis has already shown correlation between severe Chronic Periodontitis (CP) cases with human papiloma virus (HPV). Hence, we aimed to explore deep-seated infected granulation tissue removed during periodontal flap surgery procedures for residential bacterial species between HPV+ and HVP- CP cases, which may serve as good predisposition marker for oral cancer. All CP-granulation samples showed the prominence of Firmicutes, Proteobacteria, and Bacteroidetes phyla with an abundance of gram negative anaerobes, except Streptococcus. In Beta diversity nonmetric multidimensional scaling plot, the random distribution of species was observed between HPV+ and HPV- CP granulation-samples. However, an abundance of Capnocytophaga ochracea was observed in HPV+ CP samples (p<0.05), while porphyromonas endodontalis, macellibacteroides fermentas, treponema phagedenis, and campylobacter rectus species were highly abundant in hpv- cp samples (p<0.05). the differential richness leads altered functions related to mismatch-repair nucleotide excision-repair cytoskeleton-proteins. hence, abundance of gram negative bacterial between hpv+ granulation-samples under anaerobic conditions may release virulence factors which alter pathways favouring carcinogenesis. these serve as good predisposition marker for oral-cancer.
Journal: BioMed research international
DOI: 10.1155/2019/8163591
Year: 2019