July 7, 2019  |  

Complete genome sequence of Lactobacillus salivarius Ren, a probiotic strain with anti-tumor activity.

Authors: Sun, Erna and Ren, Fazheng and Liu, Songling and Ge, Shaoyang and Zhang, Ming and Guo, Huiyuan and Jiang, Lu and Zhang, Hao and Zhao, Liang

Lactobacillus salivarius Ren (LsR) (CGMCC No. 3606) is a probiotic strain that was isolated from the feces of a healthy centenarian living in Bama, Guangxi, China. Previous studies have shown that this strain decreases 4-nitroquinoline 1-oxide (4-NQO)-induced genotoxicity in vitro. It also suppresses 4-NQO-induced oral carcinogenesis and 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis, and therefore may be used as an adjuvant therapeutic agent for cancer. Here, we report the complete genome sequence of LsR that consists of a circular chromosome of 1751,565bp and two plasmids (pR1, 176,951bp; pR2, 49,848bp). Copyright © 2015 Elsevier B.V. All rights reserved.

Journal: Journal of biotechnology
DOI: 10.1016/j.jbiotec.2015.06.399
Year: 2015

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