Pacific Biosciences Enhances Performance and Affordability of Key Applications on the Sequel System
Wednesday, March 7, 2018
With this release the Sequel System can achieve up to 10 Gb per SMRT Cell for genomic libraries, effectively doubling the throughput when using ultra-long inserts (>40 kb) for de novo genome assembly. For targeted and RNA sequencing, customers can achieve up to 20 Gb per SMRT Cell. Since the SMRT Sequencing technology was first commercialized in 2011, Pacific Biosciences has increased the throughput per SMRT Cell 1000-fold. These ongoing throughput increases provide a significant cost savings for sequencing projects in the human, plant, and animal markets, which allows researchers the opportunity to increase the size and scope of their projects.
For human whole genome sequencing (WGS) studies, the new improvements support sensitive detection of structural variants with as little as 5- to 10-fold coverage per individual. As a result, customers can now complete low-cost WGS studies in thousands of individuals using fewer SMRT Cells. Sequel System users can obtain 10-fold coverage using as few as 4 SMRT Cells per sample and population genetics projects can be conducted with 5-fold coverage using as few as 2 SMRT Cells per sample. Pacific Biosciences also offers a structural variation project calculator to inform structural variant study designs.
This release improves the sensitivity of the Iso-Seq method to characterize an organism’s transcriptome. For long amplicons (>3 kb), the new polymerase increases the number of high-quality sequences per SMRT Cell, reducing costs for HLA sequencing and other targeted applications. Further, software enhancements for multiplexed samples simplify the analytical workflow.
Dr. Nezih Cereb, CEO and co-founder of HistoGenetics, was one of several early access users for this release. “By introducing SMRT Sequencing for routine HLA testing, HistoGenetics set the new gold standard. To date, we have run 475,000 samples on PacBio systems in our high-volume HLA typing lab. With these new Sequel System improvements, we are achieving increased throughput as well as saving time.”
“Our market-leading, long-read sequencing technology continues to reveal new insights in genomics that cannot be reliably detected using other sequencing methods, as evidenced by the more than 3,200 scientific publications featuring SMRT Sequencing,” said
More information about the Sequel System is available at: https://www.pacb.com/sequel/.
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Source: Pacific Biosciences, Inc.