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Technical Note on Sample Preparation

Single Molecule, Real-Time (SMRT) Sequencing uses the natural process of DNA replication to sequence long single molecules of native DNA. As such, starting with high-quality, high molecular weight genomic DNA will result in better performance across difficult to sequence regions of the genome. Before choosing your DNA isolation method, please refer to our Technical Note on Sample Collection for guidance on collection, treatment, and storage of various sample types.


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