Blog
October 29, 2014
‘Revolutionizing HLA Typing’: Uppsala’s Ulf Gyllensten on How Long Reads Give Access to New Areas of the Human Genome
In a recent interview with Theral Timpson — part of Mendelspod’s series on long-read sequencing — Ulf Gyllensten, a scientist at Uppsala University, spoke about using PacBio® technology for HLA…
October 21, 2014
Data Release: Whole Human Transcriptome from Brain, Heart, and Liver
In higher eukaryotic organisms, like humans, RNA transcripts from the vast majority of genes are alternatively spliced. Alternative splicing dramatically increases the protein-coding potential of eukaryotic genomes and its regulation…
October 20, 2014
SMRT Sequencing for the HLA Complex: PacBio Goes to ASHI
This week marks the 40th annual meeting of the American Society for Histocompatibility and Immunogenetics, better known in the community as ASHI. The PacBio® team is looking forward to attending;…
October 15, 2014
New Chemistry Boosts Average Read Length to 10 kb – 15 kb for PacBio® RS II
We are pleased to announce the launch of our new reagent kit, P6-C4, which represents the next generation of our polymerase as well as our chemistry. This kit replaces the…
October 10, 2014
ASHG 2014: A New Look at the Human Genome with Long-Read Sequencing
Scientists around the world are getting ready for the annual meeting of the American Society of Human Genetics taking place October 18-22 at the San Diego Convention Center. We’re looking…
October 9, 2014
New Brain Study Reveals Higher Molecular Diversity from Alternative Splicing
A new paper from scientists in Switzerland and the US adds to recent findings about diversity of neuronal transcripts in the mammalian brain. The authors report that this study was…
October 6, 2014
‘The Quality of PacBio Data Is Beyond Compare’: Eric Schadt on Applications of SMRT Sequencing to Human Genetics
As part of its continuing series on long-read sequencing, last week Mendelspod aired an engaging interview with Eric Schadt, Professor & Chair of Genetics and Genomic Sciences, and Director of…
October 2, 2014
‘We’re Going to Find the Keys’: Dan Geraghty Discusses an Approach to Understanding Causal Genetic Variation
Dan Geraghty, a researcher at Fred Hutchinson Cancer Research Center and CEO of Scisco Genetics, has spent much of his career focused on the genetics of immune response. Recently he…
September 30, 2014
New Papers Detail Complexity of Methylome-Related Virulence in Human Pathogens
In two new publications, one published today, scientists from Australia, Italy, the UK, and the US report critical and surprising new findings about DNA methylation-related complexity of bacteria. Adding to…
September 23, 2014
Science Perspective: “Tracking Antibiotic Resistance”
In the current issue of Science there is an interesting Perspective by Scott Beatson and Mark Walker of the University of Queensland discussing research published this week in Science Translational…
September 22, 2014
Maryland Scientists Produce High-Quality, Cost-Effective Genome Assembly of Loa loa Roundworm Using SMRT Sequencing
A paper just released in BMC Genomics details what authors call “the most complete filarial nematode assembly published thus far at a fraction of the cost of previous efforts.” The…
September 17, 2014
NIH Study: Finished Genomes Provide Actionable Data to Combat Spread of Drug-Resistant Bacteria
A study launched over concerns around hospital-acquired infections has led to a recommendation for better microbial screening of patients upon admission. The research, from scientists at several NIH institutes, found…
September 11, 2014
The Rise of Long Reads: Mendelspod Podcast Series
Mendelspod host Theral Timpson kicked off a new podcast series this week on long-read sequencing that will include interviews with luminaries in the genomics field. Check out this introductory article…
September 9, 2014
Genome Analysis of Unicellular Organism Reveals Frequent, Massive Reshuffling
A recent publication from senior author Laura Landweber at Princeton University offers a remarkable and unexpected look at sweeping genomic rearrangements in a unicellular organism. “The Architecture of a Scrambled…
August 18, 2014
Genome-Wide Methylation in Human Microbiome Samples
Scientists in Florida and Finland recently published a report of their work studying methylation patterns in two human microbiome samples. While microbiome studies have become quite popular, the authors note…