Blog
June 27, 2023
Sequencing with the Revio system is as easy as it is powerful
The Revio system was built with the belief that game-changing technology should be simple to use. For a technology to be truly revolutionary it should deliver superior performance in conjunction…
June 14, 2023
A HiFi movement – reference pangenomes
Fresh off the special Nature issue last month on the first human pangenome reference (featured in a previous blog), the first regional human pangenome reference study, entitled A Pangenome Reference…
June 7, 2023
Cracking cancer: Using long-read RNA sequencing for cancer neoantigen discovery
When developing effective personalized immunotherapies, such as cancer vaccines, a pivotal factor lies in uncovering tumor neoantigens that can serve as crucial therapeutic targets. Traditionally, neoantigen discovery heavily relied on…
May 24, 2023
Beyond short reads: Harnessing long-read sequencing for population-scale genomic insights
Large-scale population sequencing programs have a number of important research goals and outcomes. These include: Generating a comprehensive catalogue of genetic variation to reflect the genetic diversity in a target…
May 18, 2023
Sequencing 101: Sequencing coverage
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…
April 27, 2023
HiFi whole genomes could one day replace short-read genome and exome sequencing
In recent years, whole exome sequencing (WES) has become a popular method for identifying the genetic underpinnings of disease in both research and clinical settings. However, because an exome is…
April 25, 2023
The HiFi difference – a better cell atlas with full-length isoform sequencing
Understanding the myriad of different cell types, states, and their functions is essential to understanding biology. Cell atlas projects and consortia aim to map different cell types in tissues, organs,…
April 21, 2023
Earth Day 2023: Can microbial communities turn plastic waste into sustainable food?
With Earth Day almost here, it is important to remember that our planet is made up of countless interconnected parts, from vast oceans to the microscopic world of microbes. Despite…
April 20, 2023
VAMOS! Discover hidden VNTRs with long reads
See how the Chaisson lab created a new method to characterize human VNTR variation with PacBio long-read sequencing. Structural variants are hard to find with short-read sequencing methods At present,…
April 14, 2023
HiFi metagenomics sees performance enhancements across the board
The Revio system offers faster and more cost-effective long-read sequencing for metagenomics researchers, allowing for more high-quality and complete microbial datasets and access to new frontiers of discovery. The best…
April 11, 2023
The power of accurate long-read RNA sequencing for fusion gene detection in cancer research
pbfusion is a new software tool for detecting gene fusions and other transcriptional abnormalities in PacBio Iso-Seq data. The advancement of cancer research depends on the ability to accurately detect…
March 28, 2023
Long-read sequencing: the key to a more complete cancer transcriptome
Uncover the mysteries of RNA dysregulation in cancer Our understanding of the complex biology of cancers is currently limited by the sequencing technology that we have available. For example, a…
March 21, 2023
Scaling long-read sequencing throughput and accessibility with deep learning and NVIDIA
Written by: Menzies Chen, Director, Product Management, Informatics With the launch of the Revio system, PacBio is bringing a host of technologies together to increase scale for HiFi long-read…
March 9, 2023
Introducing HiFiCNV – copy number calling optimized for HiFi reads
Get more from your HiFi reads with HiFiCNV, a powerful new software tool for capturing large copy number variants throughout the genome. Why CNVs and HiFi reads are important Copy…
March 7, 2023
Shining a light on dark genes
Countries around the world have recognized the value of precision health and population genomics research initiatives. They have launched efforts to sequence thousands to millions of genomes in order to…