Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
A HiFi movement: Isoform-resolved cell atlases
Cellular cartography has been just as important for biologists to navigate the complex topography of living systems as was the mapping of the earth’s landscapes for explorers hundreds of years…
Beyond borders: The 2023 Discoveries Roadshow ignites curiosity worldwide
Onso short-read sequencing systems are no longer available through PacBio Scientific breakthroughs are rarely achieved in isolation. They require collaboration, cutting-edge techniques, and a platform where scientists can come together…
The next era of plant + animal genomics has begun
The new Revio long-read sequencing system, with its first customer shipment in March 2023, has changed the game in genomics. It enables researchers to access an entirely new echelon of…
Sequencing 101: The SMRT Cell in PacBio long-read sequencing
If you have ever clicked around the PacBio website or attended a workshop or webinar discussing PacBio long-read sequencing technology, then you have probably seen or heard about SMRT (Single…
Population genomics isn’t ‘one-size-fits-all’
Delve deeper into the importance of capturing diversity with population-specific reference pangenomes. The movement towards the development of pangenomes is gaining steam, bringing the reality of truly personalized medicine closer….
Sequencing with the Revio system is as easy as it is powerful
The Revio system was built with the belief that game-changing technology should be simple to use. For a technology to be truly revolutionary it should deliver superior performance in conjunction…
A HiFi movement – reference pangenomes
Fresh off the special Nature issue last month on the first human pangenome reference (featured in a previous blog), the first regional human pangenome reference study, entitled A Pangenome Reference…
Cracking cancer: Using long-read RNA sequencing for cancer neoantigen discovery
When developing effective personalized immunotherapies, such as cancer vaccines, a pivotal factor lies in uncovering tumor neoantigens that can serve as crucial therapeutic targets. Traditionally, neoantigen discovery heavily relied on…
Beyond short reads: Harnessing long-read sequencing for population-scale genomic insights
Large-scale population sequencing programs have a number of important research goals and outcomes. These include: Generating a comprehensive catalogue of genetic variation to reflect the genetic diversity in a target…
Sequencing 101: Sequencing coverage
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…
HiFi whole genomes could one day replace short-read genome and exome sequencing
In recent years, whole exome sequencing (WES) has become a popular method for identifying the genetic underpinnings of disease in both research and clinical settings. However, because an exome is…
The HiFi difference – a better cell atlas with full-length isoform sequencing
Understanding the myriad of different cell types, states, and their functions is essential to understanding biology. Cell atlas projects and consortia aim to map different cell types in tissues, organs,…
Earth Day 2023: Can microbial communities turn plastic waste into sustainable food?
With Earth Day almost here, it is important to remember that our planet is made up of countless interconnected parts, from vast oceans to the microscopic world of microbes. Despite…
VAMOS! Discover hidden VNTRs with long reads
See how the Chaisson lab created a new method to characterize human VNTR variation with PacBio long-read sequencing. Structural variants are hard to find with short-read sequencing methods At present,…
HiFi metagenomics sees performance enhancements across the board
The Revio system offers faster and more cost-effective long-read sequencing for metagenomics researchers, allowing for more high-quality and complete microbial datasets and access to new frontiers of discovery. The best…